Universität zu Köln

Schlaak, M., Kurschat, P., Shimabukuro-Vornhagen, A., Scheid, C., Chemnitz, J., Stadler, R., von Bergwelt-Baildon, M. and Theurich, S. (2011). Donor lymphocyte infusions combined with systemic PUVA/bexarotene as an effective bimodal immunologic approach in a patient with relapsed cutaneous T cell lymphoma after allogeneic stem cell transplantation. Transpl. Immunol., 25 (2-3). S. 163 - 167. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 0966-3274

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Abstract

One central challenge of allogeneic stem cell transplantation is the positive correlation between graft versus lymphoma effect (GvL) and graft-versus-host disease (GvHD). To date, specific targeting of GvL antigens with effector T cells and of GvHD antigens with specific regulatory T cells remains the subject of experimental research. In clinical reality, negative modulation of GvHD, e.g. by immunosuppression, reduces GvL and positive modulation of GvL, e.g. by donor lymphocyte infusions, often amplifies GvHD. Clinically feasible strategies to induce GvL whiles imultaneously reducing GvHD are urgently needed. Here, we report the case of an early relapsed primary cutaneous T cell lymphoma in tumor stage after allogeneic stem cell transplantation which was successfully treated with a parallel administration of donor lymphocyte infusions (DLI) and systemic PUVA and bexarotene which led to sustained complete remission without onset of acute GvHD. After termination of the treatment with PUVA/bexarotene subacute chronic GvHD occurred but was subsequently brought under control by extracorporeal photopheresis. We suggest that the combination of DLI and PUVA/bexarotene might be an interesting immunologic bimodal treatment option which warrants further investigation. (C) 2011 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schlaak, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurschat, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shimabukuro-Vornhagen, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheid, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chemnitz, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stadler, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED von Bergwelt-Baildon, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Theurich, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-489490
DOI:	10.1016/j.trim.2011.06.008
Journal or Publication Title:	Transpl. Immunol.
Volume:	25
Number:	2-3
Page Range:	S. 163 - 167
Date:	2011
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	0966-3274
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VERSUS-HOST-DISEASE; MYCOSIS-FUNGOIDES; SEZARY-SYNDROME; THERAPY Multiple languages Immunology; Transplantation Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48949