Universität zu Köln

Halbsguth, Teresa V., Boell, Boris, Borchmann, Peter and Diehl, Volker (2011). The Unique Characteristics and Management of Patients Over 60 Years of Age with Classic Hodgkin Lymphoma. Curr. Hematol. Malig. Rep., 6 (3). S. 164 - 172. PHILADELPHIA: CURRENT MEDICINE GROUP. ISSN 1558-822X

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Abstract

In recent decades, the prognosis of Hodgkin lymphoma has been substantially improved, but these successes have been restricted to younger patients and could not be translated into a major benefit for older patients, especially those with advanced-stage disease. Major problems in treating older patients include a different biology, frailty, comorbidities, and poorer tolerance of therapy. Additionally, these patients are often excluded from randomized trials, so an evidence-based standard of care is lacking. Importantly, the proportion of older patients with HL will increase over the next 50 years. Currently, ABVD (Adriamycin [doxorubicin], bleomycin, vinblastine, and dacarbazine) is considered to be the gold standard, even though it has some toxicity in older patients and prospective data are not available. Thus, further studies are required, including the assessment of comorbidities and the incorporation of new drugs such as immunomodulatory agents, antibody-drug conjugates, mTOR inhibitors, or histone deacetylase (HDAC) inhibitors.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Halbsguth, Teresa V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boell, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Borchmann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Diehl, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-490223
DOI:	10.1007/s11899-011-0089-7
Journal or Publication Title:	Curr. Hematol. Malig. Rep.
Volume:	6
Number:	3
Page Range:	S. 164 - 172
Date:	2011
Publisher:	CURRENT MEDICINE GROUP
Place of Publication:	PHILADELPHIA
ISSN:	1558-822X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COLONY-STIMULATING FACTOR; LARGE-CELL LYMPHOMA; ELDERLY-PATIENTS; OLDER PATIENTS; TASK-FORCE; COPP-ABVD; DISEASE; CHEMOTHERAPY; REGIMEN; CANCER Multiple languages Oncology; Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49022