Universität zu Köln

Vallboehmer, Daniel, Brabender, Jan, Grimminger, Peter ORCID: 0000-0002-1859-9213, Schroeder, Wolfgang and Hoelscher, Arnulf H. (2011). Predicting response to neoadjuvant therapy in esophageal cancer. Expert Rev. Anticancer Ther, 11 (9). S. 1449 - 1456. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1744-8328

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Abstract

Despite improvements in preoperative staging, surgical techniques and postoperative care, the 5-year survival rate of patients with locally advanced esophageal cancer remains only approximately 15-40%. Therefore, multimodality treatment options have been widely promoted in the therapy of this malignant disease. However, recent meta-analyses evaluating randomized trials of neoadjuvant therapy protocols prior to surgery for patients with advanced esophageal cancer showed only modest improvement of survival for the whole treatment group. Among these patients, those with excellent histopathologic response seem to benefit greatly from neoadjuvant regimens. Therefore, predictive markers to allow individualization of multimodality therapy in locally advanced esophageal cancer are needed to identify those who will benefit the most. Unfortunately, there is still a great lack of markers for response assessment in patients with esophageal cancer undergoing multimodality therapy. Endoscopy, endoscopic biopsies, computed tomography and endoscopic ultrasound do not seem to provide reliable information for assessing the response to neoadjuvant therapy. Whether F-18-fluorodeoxyglucose-PET can effectively characterize responders in neoadjuvant therapy protocols remains controversial. Finally, although results of mostly retrospective studies on molecular factors for response assessment in esophageal cancer patients are promising, these markers do not yet provide a reliable and cost-effective molecular tool for utilization in clinical practice.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Vallboehmer, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Brabender, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Grimminger, Peter UNSPECIFIED orcid.org/0000-0002-1859-9213 UNSPECIFIED Schroeder, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoelscher, Arnulf H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-490319
DOI:	10.1586/ERA.11.126
Journal or Publication Title:	Expert Rev. Anticancer Ther
Volume:	11
Number:	9
Page Range:	S. 1449 - 1456
Date:	2011
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1744-8328
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MINOR HISTOPATHOLOGICAL RESPONSE; POSITRON-EMISSION-TOMOGRAPHY; RANDOMIZED CONTROLLED-TRIALS; ENDOTHELIAL GROWTH-FACTOR; MESSENGER-RNA EXPRESSION; SQUAMOUS-CELL CARCINOMA; GASTROESOPHAGEAL JUNCTION; TUMOR-REGRESSION; PREOPERATIVE CHEMORADIOTHERAPY; CYCLOOXYGENASE-2 EXPRESSION Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49031