Universität zu Köln

Er, Fikret, Ederer, Stefan, Nia, Amir M., Caglayan, Evren, Dahlem, Kristina M., Semmo, Nasser and Gassanov, Natig (2010). Accuracy of Doppler-Echocardiographic Mean Pulmonary Artery Pressure for Diagnosis of Pulmonary Hypertension. PLoS One, 5 (12). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Background: The validity of Doppler echocardiographic (DE) measurement of systolic pulmonary artery pressure (sPAP) has been questioned. Recent studies suggest that mean pulmonary artery pressure (mPAP) might reflect more accurately the invasive pressures. Methodology/Principal Findings: 241 patients were prospectively studied to evaluate the diagnostic accuracy of mPAP for the diagnosis of PH. Right heart catheterization (RHC) and DE were performed in 164 patients mainly for preoperative evaluation of heart valve dysfunction. The correlation between DE and RHC was better when mPAP (r = 0.93) and not sPAP (r = 0.81) was assessed. Bland-Altman analysis revealed a smaller variation of mPAP than sPAP. The following ROC analysis identified that a mPAP >= 25.5 mmHg is useful for the diagnosis of PH. This value was validated in an independent cohort of patients (n = 50) with the suspicion of chronic-thromboembolic pulmonary hypertension. The calculated diagnostic accuracy was 98%, based on excellent sensitivity of 98% and specificity of 100%. The corresponding positive and negative predictive values were 100%, respectively 88%. Conclusion: mPAP has been found to be highly accurate for the initial diagnosis of PH. A cut-off value of 25.5 mmHg might be helpful to avoid unnecessary RHC and select patients in whom RHC might be beneficial.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Er, Fikret UNSPECIFIED UNSPECIFIED UNSPECIFIED Ederer, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Nia, Amir M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Caglayan, Evren UNSPECIFIED UNSPECIFIED UNSPECIFIED Dahlem, Kristina M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Semmo, Nasser UNSPECIFIED UNSPECIFIED UNSPECIFIED Gassanov, Natig UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-490439
DOI:	10.1371/journal.pone.0015670
Journal or Publication Title:	PLoS One
Volume:	5
Number:	12
Date:	2010
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INFERIOR VENA-CAVA; RIGHT HEART; AMERICAN-SOCIETY; EUROPEAN-ASSOCIATION; STANDARDS COMMITTEE; TASK-FORCE; GUIDELINES; RECOMMENDATIONS; QUANTIFICATION; CATHETERIZATION Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49043