Universität zu Köln

Pantulu, N. Deepa, Pallasch, Christian P. ORCID: 0000-0001-5675-6905, Kurz, Anna Kordelia, Kassem, Ahmad, Frenzel, Lukas, Sodenkamp, Sebastian, Kvasnicka, Hans Michael ORCID: 0000-0002-3081-1395, Wendtner, Clemens M. and zur Hausen, Axel (2010). Detection of a novel truncating Merkel cell polyomavirus large T antigen deletion in chronic lymphocytic leukemia cells. Blood, 116 (24). S. 5280 - 5285. WASHINGTON: AMER SOC HEMATOLOGY. ISSN 1528-0020

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Abstract

Merkel cell polyomavirus (MCPyV) is detected in approximately 80% of Merkel cell carcinomas (MCC). Yet, clonal integration and truncating mutations of the large T antigen (LTAg) of MCPyV are restricted to MCC. We tested the presence and mutations of MCPyV in highly purified leukemic cells of 70 chronic lymphocytic leukemia (CLL) patients. MCPyV was detected in 27.1% (n = 19) of these CLL cases. In contrast, MCPyV was detected only in 13.4% of normal controls (P < .036) in which no LTAg mutations were found. Mutational analyses revealed a novel 246bp LTAg deletion in the helicase gene in 6 of 19 MCPyV-positive CLL cases. 2 CLL cases showed concomitant mutated and wild-type MCPyV. Immunohistochemistry revealed protein expression of the LTAg in MCPyV-positive CLL cases. The detection of MCPyV, including LTAg deletions and LTAg expression in CLL cells argues for a potential role of MCPyV in a significant subset of CLL cases. (Blood. 2010;116(24):5280-5284)

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pantulu, N. Deepa UNSPECIFIED UNSPECIFIED UNSPECIFIED Pallasch, Christian P. UNSPECIFIED orcid.org/0000-0001-5675-6905 UNSPECIFIED Kurz, Anna Kordelia UNSPECIFIED UNSPECIFIED UNSPECIFIED Kassem, Ahmad UNSPECIFIED UNSPECIFIED UNSPECIFIED Frenzel, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Sodenkamp, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Kvasnicka, Hans Michael UNSPECIFIED orcid.org/0000-0002-3081-1395 UNSPECIFIED Wendtner, Clemens M. UNSPECIFIED UNSPECIFIED UNSPECIFIED zur Hausen, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-490786
DOI:	10.1182/blood-2010-02-269829
Journal or Publication Title:	Blood
Volume:	116
Number:	24
Page Range:	S. 5280 - 5285
Date:	2010
Publisher:	AMER SOC HEMATOLOGY
Place of Publication:	WASHINGTON
ISSN:	1528-0020
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CARCINOMA; EXPRESSION; SKIN; TUMORS; MCV Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49078