Universität zu Köln

Korkmaz, Yueksel, Klinz, Franz-Josef, Beikler, Thomas, Blauhut, Thorsten, Schneider, Kurt, Addicks, Klaus, Bloch, Wilhelm and Raab, Wolfgang H-M (2010). The Ca2+-binding protein calretinin is selectively enriched in a subpopulation of the epithelial rests of Malassez. Cell Tissue Res., 342 (3). S. 391 - 401. NEW YORK: SPRINGER. ISSN 1432-0878

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Abstract

During tooth development, the inner and outer enamel epithelia fuse by mitotic activity to produce a bilayered epithelial sheath termed Hertwig's epithelial root sheath (HERS). The epithelial rests of Malassez (ERM) are the developmental residues of HERS and remain in the adult periodontal ligament (PDL). Although the cellular regulation of the Ca2+-binding proteins parvalbumin, calbindin-D28k, and calretinin has been reported in the inner and outer enamel epithelia during tooth development, an involvement of Ca2+-binding proteins in the ERM has not so far been characterized. Among the three Ca2+-binding proteins tested (calbindin D28k, parvalbumin, calretinin), we have only been able to detect calretinin in a subpopulation of adult rat molar ERM, by using quantitative immunohistochemical and confocal immunofluorescence techniques. TrkA (a marker for ERM) is present in numerous epithelial cell clusters, whereas calretinin has been localized in the cytosol and perinuclear region of a subpopulation of TrkA-positive cells. We conclude that, in inner and outer enamel epithelial cells, Ca2+ is regulated by calbindin, parvalbumin, and calretinin during tooth development, whereas in the ERM of adult PDL, Ca2+ is regulated only by calretinin. The expression of Ca2+-binding proteins is restricted in a developmental manner in the ERM.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Korkmaz, Yueksel UNSPECIFIED UNSPECIFIED UNSPECIFIED Klinz, Franz-Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED Beikler, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Blauhut, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Kurt UNSPECIFIED UNSPECIFIED UNSPECIFIED Addicks, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Raab, Wolfgang H-M UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-491239
DOI:	10.1007/s00441-010-1076-3
Journal or Publication Title:	Cell Tissue Res.
Volume:	342
Number:	3
Page Range:	S. 391 - 401
Date:	2010
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-0878
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CALCIUM-BINDING-PROTEIN; FIBER-TYPE COMPOSITION; HUMAN JAW MUSCLES; PERIODONTAL-LIGAMENT; ROOT-FORMATION; RAT INCISOR; CELL RESTS; CALBINDIN D28K; MOLAR TEETH; WIDR CELLS Multiple languages Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49123