Universität zu Köln

Boell, Boris, Borchmann, Peter and Diehl, Volker (2010). Emerging drugs for Hodgkin's lymphoma. Expert Opin Emerg. Drugs, 15 (4). S. 585 - 596. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1744-7623

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Abstract

Importance of the field: Although to date most patients with Hodgkin's lymphoma (HL) can be cured, the current treatment is associated with acute and long-term complications such as infertility, cardiovascular damage and secondary malignancies. Moreover, novel effective therapies are urgently needed for elderly patients and for patients relapsing after high-dose chemotherapy. Areas covered in this review: Currently emerging promising approaches include drugs targeting cell surface structures by mAbs and immunotoxins, as well as small molecules targeting intracellular proteins. This article includes clinical trials published within the past 3 decades and early results reported in international conferences. What the reader will gain: This article summarizes the biological basis and early clinical data on emerging drugs for HL. Take home message: To date, several new drugs are being tested for HL that are expected to change the approach in both first-line and relapsed patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Boell, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Borchmann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Diehl, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-491418
DOI:	10.1517/14728214.2010.505602
Journal or Publication Title:	Expert Opin Emerg. Drugs
Volume:	15
Number:	4
Page Range:	S. 585 - 596
Date:	2010
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1744-7623
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REED-STERNBERG CELLS; EPSTEIN-BARR-VIRUS; NF-KAPPA-B; POSITRON-EMISSION-TOMOGRAPHY; IMMUNOGLOBULIN GENE REARRANGEMENTS; HISTONE DEACETYLASE INHIBITORS; INTERNATIONAL PROGNOSTIC SCORE; TREATMENT FAILURE; CYCLE ARREST; AKT KINASE Multiple languages Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49141