Universität zu Köln

Fricke, Oliver, Beccard, Ralf, Semler, Oliver and Schoenau, Eckhard (2010). Analyses of muscular mass and function: the impact on bone mineral density and peak muscle mass. Pediatr. Nephrol., 25 (12). S. 2393 - 2401. NEW YORK: SPRINGER. ISSN 1432-198X

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Abstract

Bone density and bone mass are commonly regarded as the essential parameters to describe fracture risk in osteology. Because fractures primarily depend on bone strength and secondarily on bone mass and density, bone strength should be the main parameter to describe fracture risk. The quantitative description of bone strength has the prerequisite that bone geometry is assessed despite bone density. Thus, volumetric osteodensitometric methods should be preferred, which enable the physician to evaluate parameters primarily associated with bone modeling or remodeling. Modeling describes the adaptation of bone geometry to applied muscular forces in contrast to remodeling representing bone turnover. The adaptation of bone geometry to muscle forces led to the term functional muscle-bone unit, which enables the physician to differentiate between primary and secondary bone diseases. Primary bone diseases are characterized by a defective adaptation of bone to muscle forces in contrast to secondary bone diseases, which are primary diseases of the neuromuscular system. Because muscle forces are essential in the feedback loop of bone adaptation to forces (mechanostat), the assessment of muscle function has become an essential part of osteologic diagnostics in pediatrics. Dynamometric and mechanographic methods have been introduced to properly characterize kinetic aspects of muscle function in children and adolescents. Therefore, emphasis should be put on the assessment of muscle function despite the evaluation of osteodensitometric parameters in pediatric osteology.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fricke, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Beccard, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Semler, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenau, Eckhard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-491988
DOI:	10.1007/s00467-010-1517-y
Journal or Publication Title:	Pediatr. Nephrol.
Volume:	25
Number:	12
Page Range:	S. 2393 - 2401
Date:	2010
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-198X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SKELETAL PHYSIOLOGY; CHILDREN; STRENGTH; OSTEOPOROSIS; MECHANOSTAT; ASSOCIATION; ADOLESCENTS; FRACTURES; DISEASE; FOREARM Multiple languages Pediatrics; Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49198