Universität zu Köln

Lynch, Jeremy A. and Desplan, Claude ORCID: 0000-0002-6914-1413 (2010). Novel modes of localization and function of nanos in the wasp Nasonia. Development, 137 (22). S. 3813 - 3822. CAMBRIDGE: COMPANY OF BIOLOGISTS LTD. ISSN 0950-1991

Full text not available from this repository.

Abstract

Abdominal patterning in Drosophila requires the function of nanos (nos) to prevent translation of hunchback (hb) mRNA in the posterior of the embryo. nos function is restricted to the posterior by the translational repression of mRNA that is not incorporated into the posteriorly localized germ plasm during oogenesis. The wasp Nasonia vitripennis (Nv) undergoes a long germ mode of development very similar to Drosophila, although the molecular patterning mechanisms employed in these two organisms have diverged significantly, reflecting the independent evolution of this mode of development. Here, we report that although Nv nanos (Nv-nos) has a conserved function in embryonic patterning through translational repression of hb, the timing and mechanisms of this repression are significantly delayed in the wasp compared with the fly. This delay in Nv-nos function appears to be related to the dynamic behavior of the germ plasm in Nasonia, as well as to the maternal provision of Nv-Hb protein during oogenesis. Unlike in flies, there appears to be two functional populations of Nv-nos mRNA: one that is concentrated in the oosome and is taken up into the pole cells before evidence of Nv-hb repression is observed; another that forms a gradient at the posterior and plays a role in Nv-hb translational repression. Altogether, our results show that, although the embryonic patterning function of nos orthologs is broadly conserved, the mechanisms employed to achieve this function are distinct.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lynch, Jeremy A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Desplan, Claude UNSPECIFIED orcid.org/0000-0002-6914-1413 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-492469
DOI:	10.1242/dev.054213
Journal or Publication Title:	Development
Volume:	137
Number:	22
Page Range:	S. 3813 - 3822
Date:	2010
Publisher:	COMPANY OF BIOLOGISTS LTD
Place of Publication:	CAMBRIDGE
ISSN:	0950-1991
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MESSENGER-RNA LOCALIZATION; SEGMENTATION GENE HUNCHBACK; GERM-CELL DEVELOPMENT; DROSOPHILA EMBRYO; AXIS FORMATION; POSTERIOR DETERMINANT; ACCESSORY NUCLEI; BEETLE TRIBOLIUM; BINDING PROTEIN; BICOID PROTEIN Multiple languages Developmental Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49246