Neumann, Sascha, Schneider, Maria, Daugherty, Rebecca L., Gottardi, Cara J., Eming, Sabine A., Beijer, Asa, Noegel, Angelika A. and Karakesisoglou, Iakowos (2010). Nesprin-2 Interacts with alpha-Catenin and Regulates Wnt Signaling at the Nuclear Envelope. J. Biol. Chem., 285 (45). S. 34932 - 34939. BETHESDA: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC. ISSN 0021-9258
Full text not available from this repository.Abstract
Nesprins and emerin are structural nuclear envelope proteins that tether nuclei to the cytoskeleton. In this work, we identified the cytoskeleton-associated alpha-N/E-catenins as novel nesprin-2-binding partners. The association involves the C termini of nesprin-2 giant and alpha-N/E-catenins. alpha-E/T/N-catenins are known primarily for their roles in cadherin-mediated cell-cell adhesion. Here, we show that, in addition, alpha-catenin forms complexes with nesprin-2 that include beta-catenin and emerin. We demonstrate that the depletion of nesprin-2 reduces both the amount of active beta-catenin inside the nucleus and T-cell factor/lymphoid-enhancing factor-dependent transcription. Taken together, these findings suggest novel nesprin-2 functions in cellular signaling. Moreover, we propose that, in contrast to emerin, nesprin-2 is a positive regulator of the Wnt signaling pathway.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-492660 | ||||||||||||||||||||||||||||||||||||
DOI: | 10.1074/jbc.M110.119651 | ||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | J. Biol. Chem. | ||||||||||||||||||||||||||||||||||||
Volume: | 285 | ||||||||||||||||||||||||||||||||||||
Number: | 45 | ||||||||||||||||||||||||||||||||||||
Page Range: | S. 34932 - 34939 | ||||||||||||||||||||||||||||||||||||
Date: | 2010 | ||||||||||||||||||||||||||||||||||||
Publisher: | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | ||||||||||||||||||||||||||||||||||||
Place of Publication: | BETHESDA | ||||||||||||||||||||||||||||||||||||
ISSN: | 0021-9258 | ||||||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/49266 |
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