Universität zu Köln

Kong, Dong, Vong, Linh, Parton, Laura E., Ye, Chianping, Tong, Qingchun ORCID: 0000-0002-4561-2540, Hu, Xiaoxia, Choi, Brian, Bruening, Jens C. and Lowell, Bradford B. (2010). Glucose Stimulation of Hypothalamic MCH Neurons Involves K-ATP Channels, Is Modulated by UCP2, and Regulates Peripheral Glucose Homeostasis. Cell Metab., 12 (5). S. 545 - 553. CAMBRIDGE: CELL PRESS. ISSN 1550-4131

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Abstract

Blood glucose levels are tightly controlled, a process thought to be orchestrated primarily by peripheral mechanisms (insulin secretion by beta cells, and insulin action on muscle, fat, and liver). The brain also plays an important, albeit less well-defined role. Subsets of neurons in the brain are excited by glucose; in many cases this involves ATP-mediated closure of K-ATP channels. To understand the relevance of this, we are manipulating glucose sensing within glucose-excited neurons. In the present study, we demonstrate that glucose excitation of MCH-expressing neurons in the lateral hypothalamus is mediated by K-ATP channels and is negatively regulated by UCP2 (a mitochondrial protein that reduces ATP production), and that glucose sensing by MCH neurons plays an important role in regulating glucose homeostasis. Combined, the glucose-excited neurons are likely to play key, previously unexpected roles in regulating blood glucose.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kong, Dong UNSPECIFIED UNSPECIFIED UNSPECIFIED Vong, Linh UNSPECIFIED UNSPECIFIED UNSPECIFIED Parton, Laura E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ye, Chianping UNSPECIFIED UNSPECIFIED UNSPECIFIED Tong, Qingchun UNSPECIFIED orcid.org/0000-0002-4561-2540 UNSPECIFIED Hu, Xiaoxia UNSPECIFIED UNSPECIFIED UNSPECIFIED Choi, Brian UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruening, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lowell, Bradford B. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-492715
DOI:	10.1016/j.cmet.2010.09.013
Journal or Publication Title:	Cell Metab.
Volume:	12
Number:	5
Page Range:	S. 545 - 553
Date:	2010
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1550-4131
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BETA-CELL DYSFUNCTION; MELANIN-CONCENTRATING HORMONE; RAT-BRAIN; IN-SITU; OBESITY; PROTEIN; EXPRESSION; NUCLEUS; LEPTIN; POMC Multiple languages Cell Biology; Endocrinology & Metabolism Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49271