Universität zu Köln

Ogueta, Maite ORCID: 0000-0002-4777-8317, Cibik, Osman, Eltrop, Rouven, Schneider, Andrea and Scholz, Henrike (2010). The Influence of Adh Function on Ethanol Preference and Tolerance in Adult Drosophila melanogaster. Chem. Senses, 35 (9). S. 813 - 823. OXFORD: OXFORD UNIV PRESS. ISSN 1464-3553

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Abstract

Preference determines behavioral choices such as choosing among food sources and mates. One preference-affecting chemical is ethanol, which guides insects to fermenting fruits or leaves. Here, we show that adult Drosophila melanogaster prefer food containing up to 5% ethanol over food without ethanol and avoid food with high levels (23%) of ethanol. Although female and male flies behaved differently at ethanol-containing food sources, there was no sexual dimorphism in the preference for food containing modest ethanol levels. We also investigated whether Drosophila preference, sensitivity and tolerance to ethanol was related to the activity of alcohol dehydrogenase (Adh), the primary ethanol-metabolizing enzyme in D. melanogaster. Impaired Adh function reduced ethanol preference in both D. melanogaster and a related species, D. sechellia. Adh-impaired flies also displayed reduced aversion to high ethanol concentrations, increased sensitivity to the effects of ethanol on postural control, and negative tolerance/sensitization (i.e., a reduction of the increased resistance to ethanol's effects that normally occurs upon repeated exposure). These data strongly indicate a linkage between ethanol-induced behavior and ethanol metabolism in adult fruit flies: Adh deficiency resulted in reduced preference to low ethanol concentrations and reduced aversion to high ones, despite recovery from ethanol being strongly impaired.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ogueta, Maite UNSPECIFIED orcid.org/0000-0002-4777-8317 UNSPECIFIED Cibik, Osman UNSPECIFIED UNSPECIFIED UNSPECIFIED Eltrop, Rouven UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Scholz, Henrike UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-493062
DOI:	10.1093/chemse/bjq084
Journal or Publication Title:	Chem. Senses
Volume:	35
Number:	9
Page Range:	S. 813 - 823
Date:	2010
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1464-3553
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OVIPOSITION-SITE PREFERENCE; ALCOHOL-DEHYDROGENASE ADH; ENVIRONMENTAL ALCOHOL; BEHAVIORAL-RESPONSE; FOOD PREFERENCES; POPULATIONS; GENETICS; SIMULANS; ECOLOGY; ATTRACT Multiple languages Behavioral Sciences; Food Science & Technology; Neurosciences; Physiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49306