Universität zu Köln

Bulankova, Petra ORCID: 0000-0002-0368-5995, Riehs-Kearnan, Nina, Nowack, Moritz K., Schnittger, Arp ORCID: 0000-0001-7067-0091 and Riha, Karel ORCID: 0000-0002-6124-0118 (2010). Meiotic Progression in Arabidopsis Is Governed by Complex Regulatory Interactions between SMG7, TDM1, and the Meiosis I-Specific Cyclin TAM. Plant Cell, 22 (11). S. 3791 - 3804. ROCKVILLE: AMER SOC PLANT BIOLOGISTS. ISSN 1532-298X

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Abstract

Meiosis is a modified cell division that produces four haploid nuclei from a single diploid cell in two rounds of chromosome segregation. Here, we analyze the role of Arabidopsis thaliana SUPPRESSOR WITH MORPHOGENETIC EFFECTS ON GENITALIA7 (SMG7), THREE DIVISION MUTANT1 (TDM1), and TARDY ASYNCHRONOUS MEIOSIS (TAM) in meiotic progression. SMG7 is a conserved nonsense-mediated mRNA decay factor that is also, in Arabidopsis, essential for completion of meiosis. Examination of activating CYCLIN DEPENDENT KINASE A; 1 phosophorylation at Thr-161 suggests that the meiotic arrest observed in smg7 mutants is likely caused by a failure to downregulate cyclin-dependent kinase (CDK) activity at the end of the second meiotic division. Genetic analysis indicates that SMG7 and TDM1 act in the same pathway to facilitate exit from meiosis. We further demonstrate that the cyclin TAM is specifically expressed in meiosis I and has both stimulatory and inhibitory effects on progression to meiosis II. TAM knockouts skip the second meiotic division producing unreduced gametes, but inactivation of SMG7 or TDM1 alleviates TAM's requirement for entry into meiosis II. We propose a model that meiotic progression in Arabidopsis pollen mother cells is driven by a yet to be identified cyclin-CDK activity that is modulated by regulatory interactions between TDM1, SMG7, and TAM.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bulankova, Petra UNSPECIFIED orcid.org/0000-0002-0368-5995 UNSPECIFIED Riehs-Kearnan, Nina UNSPECIFIED UNSPECIFIED UNSPECIFIED Nowack, Moritz K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schnittger, Arp UNSPECIFIED orcid.org/0000-0001-7067-0091 UNSPECIFIED Riha, Karel UNSPECIFIED orcid.org/0000-0002-6124-0118 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-493943
DOI:	10.1105/tpc.110.078378
Journal or Publication Title:	Plant Cell
Volume:	22
Number:	11
Page Range:	S. 3791 - 3804
Date:	2010
Publisher:	AMER SOC PLANT BIOLOGISTS
Place of Publication:	ROCKVILLE
ISSN:	1532-298X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANAPHASE-PROMOTING COMPLEX; CELL-DIVISION; MITOTIC CYCLINS; SOMATIC-CELLS; PROPHASE-I; PHOSPHORYLATION; PROTEIN; EXIT; DESTRUCTION; THALIANA Multiple languages Biochemistry & Molecular Biology; Plant Sciences; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49394