Universität zu Köln

Jordan, Sabine D., Koenner, A. Christine and Bruening, Jens C. (2010). Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis. Cell. Mol. Life Sci., 67 (19). S. 3255 - 3274. BASEL: SPRINGER BASEL AG. ISSN 1420-9071

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Abstract

The central nervous system (CNS) is capable of gathering information on the body's nutritional state and it implements appropriate behavioral and metabolic responses to changes in fuel availability. This feedback signaling of peripheral tissues ensures the maintenance of energy homeostasis. The hypothalamus is a primary site of convergence and integration for these nutrient-related feedback signals, which include central and peripheral neuronal inputs as well as hormonal signals. Increasing evidence indicates that glucose and lipids are detected by specialized fuel-sensing neurons that are integrated in these hypothalamic neuronal circuits. The purpose of this review is to outline the current understanding of fuel-sensing mechanisms in the hypothalamus, to integrate the recent findings in this field, and to address the potential role of dysregulation in these pathways in the development of obesity and type 2 diabetes mellitus.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jordan, Sabine D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenner, A. Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruening, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-495200
DOI:	10.1007/s00018-010-0414-7
Journal or Publication Title:	Cell. Mol. Life Sci.
Volume:	67
Number:	19
Page Range:	S. 3255 - 3274
Date:	2010
Publisher:	SPRINGER BASEL AG
Place of Publication:	BASEL
ISSN:	1420-9071
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACTIVATED PROTEIN-KINASE; SENSITIVE K+ CHANNELS; HYPOTHALAMIC ARCUATE NUCLEUS; MELANOCYTE-STIMULATING HORMONE; INDUCED INSULIN-SECRETION; ACID SYNTHASE INHIBITOR; PANCREATIC BETA-CELLS; REDUCES FOOD-INTAKE; CHAIN FATTY-ACIDS; ENDOPLASMIC-RETICULUM STRESS Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49520