Universität zu Köln

Prenzel, K. L., Hoelscher, A. H., Vallboehmer, D., Drebber, U., Gutschow, C. A., Moenig, S. P. and Stippel, D. L. (2010). Lymph node size and metastatic infiltration in adenocarcinoma of the pancreatic head. EJSO, 36 (10). S. 993 - 997. OXFORD: ELSEVIER SCI LTD. ISSN 0748-7983

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Abstract

Background: Preoperative lymph node staging of pancreatic cancer by CT relies on the premise that malignant lymph nodes are larger than benign nodes. In imaging procedures lymph nodes >1 cm in size are regarded as metastatic nodes. The extend of lymphadenectomy and potential application of neoadjuvant therapy regimens could be dependent on this evaluation. Patients and methods: In a morphometric study regional lymph nodes from 52 patients with pancreatic cancer were analyzed. The lymph nodes were counted, the largest diameter of each node was measured, and each node was analyzed for metastatic involvement by histopathological examination. The frequency of metastatic involvement was calculated and correlated with lymph node size. Results: A total of 636 lymph nodes were present in the 52 specimens examined for this study (12.2 lymph nodes per patient). Eleven patients had a pN0 status, whereas 41 patients had lymph nodes that were positive for cancer. Five-hundred-twenty (82%) lymph nodes were tumor-free, while 116 (18%) showed metastatic involvement on histopathologic examination. The mean (+/- SD) diameter of the non-metastatic nodes was 4.3 mm, whereas infiltrated nodes had a diameter of 5.7 mm (p = 0.001). Seventy-eight (67%) of the infiltrated lymph nodes and 433 (83%) of the nonmetastatic nodes were <= 5 mm in diameter. Of 11 pN0 patients, 5 (45%) patients had at least one lymph node >= 10 mm, in contrast only 12 (29%) out of 41 pN1 patients had one lymph node >= 10 mm. Conclusion: Lymph node size is not a reliable parameter for the evaluation of metastatic involvement in patients with pancreatic cancer. (C) 2010 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Prenzel, K. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoelscher, A. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vallboehmer, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Drebber, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gutschow, C. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moenig, S. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stippel, D. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-495389
DOI:	10.1016/j.ejso.2010.06.009
Journal or Publication Title:	EJSO
Volume:	36
Number:	10
Page Range:	S. 993 - 997
Date:	2010
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	0748-7983
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENDOSCOPIC ULTRASONOGRAPHY; COMPUTED-TOMOGRAPHY; DUCTAL ADENOCARCINOMA; SPIRAL CT; CANCER; DIAGNOSIS; CARCINOMA; TUMORS Multiple languages Oncology; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49538