Universität zu Köln

Herb, Marc ORCID: 0000-0002-7533-0288, Gluschko, Alexander ORCID: 0000-0002-1090-1756 and Schramm, Michael (2021). Reactive Oxygen Species: Not Omnipresent but Important in Many Locations. Front. Cell. Dev. Biol., 9. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2296-634X

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Abstract

Reactive oxygen species (ROS), such as the superoxide anion or hydrogen peroxide, have been established over decades of research as, on the one hand, important and versatile molecules involved in a plethora of homeostatic processes and, on the other hand, as inducers of damage, pathologies and diseases. Which effects ROS induce, strongly depends on the cell type and the source, amount, duration and location of ROS production. Similar to cellular pH and calcium levels, which are both strictly regulated and only altered by the cell when necessary, the redox balance of the cell is also tightly regulated, not only on the level of the whole cell but in every cellular compartment. However, a still widespread view present in the scientific community is that the location of ROS production is of no major importance and that ROS randomly diffuse from their cellular source of production throughout the whole cell and hit their redox-sensitive targets when passing by. Yet, evidence is growing that cells regulate ROS production and therefore their redox balance by strictly controlling ROS source activation as well as localization, amount and duration of ROS production. Hopefully, future studies in the field of redox biology will consider these factors and analyze cellular ROS more specifically in order to revise the view of ROS as freely flowing through the cell.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Herb, Marc UNSPECIFIED orcid.org/0000-0002-7533-0288 UNSPECIFIED Gluschko, Alexander UNSPECIFIED orcid.org/0000-0002-1090-1756 UNSPECIFIED Schramm, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-561972
DOI:	10.3389/fcell.2021.716406
Journal or Publication Title:	Front. Cell. Dev. Biol.
Volume:	9
Date:	2021
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	2296-634X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROTEIN-TYROSINE-PHOSPHATASE; MITOCHONDRIAL COMPLEX II; INTRACELLULAR ROS LEVELS; NITRIC-OXIDE SYNTHASE; NADPH OXIDASE; HYDROGEN-PEROXIDE; SUPEROXIDE ANION; OXIDATIVE STRESS; NOX ENZYMES; LC3-ASSOCIATED PHAGOCYTOSIS Multiple languages Cell Biology; Developmental Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56197