Universität zu Köln

Garcia Borrega, Jorge ORCID: 0000-0003-1326-1560, Naendrup, Jan-Hendrik, Heindel, Katrin, Hamacher, Laura, Heger, Eva, Di Cristanziano, Veronica, Deppe, Antje-Christin, Dusse, Fabian ORCID: 0000-0001-7762-6966, Wetsch, Wolfgang Alois, Eichenauer, Dennis Alexander, Shimabukuro-Vornhagen, Alexander ORCID: 0000-0002-2351-7294, Boell, Boris and Kochanek, Matthias ORCID: 0000-0002-4766-4651 (2021). Clinical Course and Outcome of Patients with SARS-CoV-2 Alpha Variant Infection Compared to Patients with SARS-CoV-2 Wild-Type Infection Admitted to the ICU. Microorganisms, 9 (9). BASEL: MDPI. ISSN 2076-2607

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Abstract

The alpha variant of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is associated with higher transmissibility and possibly higher mortality compared with wild-type SARS-CoV-2. However, few data are available on the clinical course of infections with the alpha variant compared with wild-type SARS-CoV-2 in critically ill patients in intensive care units (ICUs). Therefore, we retrospectively analyzed patients admitted to our ICU due to SARS-CoV-2 Alpha variant infection and compared characteristics and course to patients with SARS-CoV-2 wild-type infection. The median age of patients with Alpha variant infections was 57 years compared to 62 years in the wild-type group. ICU survival was 41/80 (51%) in the Alpha variant group and 35/80 (44%) in the wild-type group (p = 0.429). Results of a matched-pair analysis based on age and sex illustrated that 45/58 patients (77.6%) in the Alpha variant group and 38/58 (65.5%) patients in the wild-type group required mechanical ventilation (p = 0.217). ICU survival was documented for 28/58 patients (48.3%) in the Alpha variant group and 27/58 patients (46.6%) in the wild-type group (p = 1). Thus, ICU mortality among patients with SARS-CoV-2 infections remains high. Although the Alpha variant group included younger patients requiring mechanical ventilation, no significant differences between patients with the SARS-CoV-2 Alpha variant and the SARS-CoV-2 wild-type, respectively, were detected with respect to clinical course and ICU mortality. For future VOCs, we believe it would be important to obtain valid and rapid data on the clinical course of critically ill patients who test positive for COVID-19 in order to perform appropriate epidemiological planning of intensive care capacity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Garcia Borrega, Jorge UNSPECIFIED orcid.org/0000-0003-1326-1560 UNSPECIFIED Naendrup, Jan-Hendrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindel, Katrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamacher, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Heger, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Di Cristanziano, Veronica UNSPECIFIED UNSPECIFIED UNSPECIFIED Deppe, Antje-Christin UNSPECIFIED UNSPECIFIED UNSPECIFIED Dusse, Fabian UNSPECIFIED orcid.org/0000-0001-7762-6966 UNSPECIFIED Wetsch, Wolfgang Alois UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichenauer, Dennis Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Shimabukuro-Vornhagen, Alexander UNSPECIFIED orcid.org/0000-0002-2351-7294 UNSPECIFIED Boell, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Kochanek, Matthias UNSPECIFIED orcid.org/0000-0002-4766-4651 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-563058
DOI:	10.3390/microorganisms9091944
Journal or Publication Title:	Microorganisms
Volume:	9
Number:	9
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-2607
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MORTALITY; LINEAGE; B.1.1.7 Multiple languages Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56305