Universität zu Köln

Herb, Marc ORCID: 0000-0002-7533-0288 and Schramm, Michael ORCID: 0000-0003-0226-9129 (2021). Functions of ROS in Macrophages and Antimicrobial Immunity. Antioxidants, 10 (2). BASEL: MDPI. ISSN 2076-3921

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Abstract

Reactive oxygen species (ROS) are a chemically defined group of reactive molecules derived from molecular oxygen. ROS are involved in a plethora of processes in cells in all domains of life, ranging from bacteria, plants and animals, including humans. The importance of ROS for macrophage-mediated immunity is unquestioned. Their functions comprise direct antimicrobial activity against bacteria and parasites as well as redox-regulation of immune signaling and induction of inflammasome activation. However, only a few studies have performed in-depth ROS analyses and even fewer have identified the precise redox-regulated target molecules. In this review, we will give a brief introduction to ROS and their sources in macrophages, summarize the versatile roles of ROS in direct and indirect antimicrobial immune defense, and provide an overview of commonly used ROS probes, scavengers and inhibitors.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Herb, Marc UNSPECIFIED orcid.org/0000-0002-7533-0288 UNSPECIFIED Schramm, Michael UNSPECIFIED orcid.org/0000-0003-0226-9129 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-563223
DOI:	10.3390/antiox10020313
Journal or Publication Title:	Antioxidants
Volume:	10
Number:	2
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-3921
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NITRIC-OXIDE SYNTHASE; NF-KAPPA-B; MITOCHONDRIAL COMPLEX II; NLRP3 INFLAMMASOME ACTIVATION; CHRONIC GRANULOMATOUS-DISEASE; PROTEIN-TYROSINE-PHOSPHATASE; OXYGEN SPECIES PRODUCTION; UBIQUINONE-BINDING-SITE; LOW-DENSITY-LIPOPROTEIN; REACTIVE OXYGEN Multiple languages Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science & Technology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56322