Universität zu Köln

Lentzen, Max-Philipp, Buller, Johannes, Riekert, Maximilian, Grandoch, Andrea, Kreppel, Matthias, Zoller, Joachim E. and Zirk, Matthias (2021). Bisphosphonate application and volumetric effects on MRONJ lesions. J. Cranio-MaxilloFac. Surg., 49 (6). S. 501 - 508. EDINBURGH: CHURCHILL LIVINGSTONE. ISSN 1878-4119

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Abstract

The purpose of this investigation was to analyze the volume of medication-related osteonecrosis of the jaw (MRONJ) lesions by semi-automatic segmentation of cone-beam computed tomography images, and correlate the results with the underlying diseases and applied medication. MRONJ lesions detected in cone-beam computed tomography images were assessed. The opensource software ITK-Snap enabled volumetric measurements of MRONJ lesions based on semiautomatic segmentation. Results were analyzed according to necrosis volume, localization, and gender. In addition, the underlying disease and the type of application of antiresorptive medication were investigated. Cone-beam computed tomography images of 66 patients were studied. 34 male and 32 female patients were included, with ages ranging from 50 to 93 years at the time of diagnosis. The mean volume was 993.24 +/- 620.94 mm3: 484.73 +/- 230.97 mm3 for the upper jaw and 1084.04 +/- 625.74 mm3 for the lower jaw. The results indicated statistically significant differences between lesions of the upper and lower jaw, regardless of gender (p = 0.003). The analysis of differences between males and females did not show any significant results ( p = 0.464), although males presented slightly larger lesions than females. With regard to the underlying disease, patients with osteoporosis presented larger volumes, whereas patients with malignant tumors presented smaller volumes. Nevertheless, no statistically significant differences according to the underlying disease (p = 0.313) were detected. However, patients with intravenous (iv) application showed statistically significantly larger lesions than patients who underwent oral or subcutaneous (s.c.) applications (p = 0.004). It seems that the osteonecrosis volume correlates with the applied antiresorptive agents. Larger MRONJ lesions should be expected in patients who receive intravenous antiresorptive therapy. (C) 2021 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lentzen, Max-Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Buller, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Riekert, Maximilian UNSPECIFIED UNSPECIFIED UNSPECIFIED Grandoch, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreppel, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoller, Joachim E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zirk, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-563859
DOI:	10.1016/j.jcms.2021.01.014
Journal or Publication Title:	J. Cranio-MaxilloFac. Surg.
Volume:	49
Number:	6
Page Range:	S. 501 - 508
Date:	2021
Publisher:	CHURCHILL LIVINGSTONE
Place of Publication:	EDINBURGH
ISSN:	1878-4119
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MEDICATION-RELATED OSTEONECROSIS; RISK-FACTORS; DENOSUMAB EXPOSURE; ZOLEDRONIC ACID; JAW; DIAGNOSIS; WOMEN; SEGMENTATION; ASSOCIATION; TOMOGRAPHY Multiple languages Dentistry, Oral Surgery & Medicine; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56385