Universität zu Köln

Lentzen, Max-Philipp ORCID: 0000-0003-2041-5687, Riekert, Maximilian, Grozinger, Philipp, Zirk, Matthias, Nickenig, Hans-Joachim, Zoeller, Joachim E. and Kreppel, Matthias (2021). Anatomical and volumetric analysis of fibro-osseous lesions of the craniofacial skeleton. J. Cranio-MaxilloFac. Surg., 49 (12). S. 1113 - 1119. EDINBURGH: CHURCHILL LIVINGSTONE. ISSN 1878-4119

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Abstract

Purpose: Our study aimed to provide volumetric data relating to fibro-osseous lesions of the craniofacial skeleton, in order to highlight risk factors due to the different entities, and to guide clinical decisions for jeopardized patients. Methods: Volumetric measurements of osteomas and ossifying fibromas were performed by applying the open-source software ITK-Snap to cone-beam computed tomography images. DICOM datasets were imported, identified, and delineated using semiautomatic segmentation; this was then verified using manual segmentation. The volumes of the lesions were computed automatically in cubic millimeters using the program. For statistical investigations, descriptive statistics and independent Student t-tests were performed. Additionally, Pearson's correlation was applied as a bivariate analysis. Values of p < 0.05 were considered significant. Results: 45 patients (11 male and 34 female) were included in this study. The mean volumes were 10.02 +/- 18.79 cm(3) for osteomas and 4.80 +/- 5.71 cm(3) for ossifying fibromas (p = 0.016). Males (12.81 +/- 20.38 cm(3)) presented significantly larger volumes than females (5.43 +/- 10.32 cm(3)) (p = 0.042). With regard to shape, morphology, and affection of surrounding anatomical structures, irregular shape (p = 0.001; p = 0.037), multilocular morphology (p = 0.001; p = 0.037), nerve affection (p = 0.001; p = 0.002), tooth affection (p = 0.001; p = 0.594), cortical bone exceedance (p = 0.033; p = 0.001), and clinically visible symptoms (p = 0.004; p = 0.001) were statistically significantly associated with a larger volume of both entities. Conclusion: Volumetric analysis revealed that osteomas significantly exceeded the mean size of ossifying fibromas, supporting the argument that special attention should be paid to this entity. In cases of difficult histopathological examination, lesions with irregular shape, multilocular morphology, nerve and tooth affection, cortical bone exceedance, and clinically visible symptoms should be considered for close clinico-radiological follow-up, irrespective of the entity. (C) 2021 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lentzen, Max-Philipp UNSPECIFIED orcid.org/0000-0003-2041-5687 UNSPECIFIED Riekert, Maximilian UNSPECIFIED UNSPECIFIED UNSPECIFIED Grozinger, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Zirk, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Nickenig, Hans-Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoeller, Joachim E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreppel, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-566638
DOI:	10.1016/j.jcms.2021.09.006
Journal or Publication Title:	J. Cranio-MaxilloFac. Surg.
Volume:	49
Number:	12
Page Range:	S. 1113 - 1119
Date:	2021
Publisher:	CHURCHILL LIVINGSTONE
Place of Publication:	EDINBURGH
ISSN:	1878-4119
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OSSIFYING FIBROMA; SEGMENTATION; DYSPLASIA Multiple languages Dentistry, Oral Surgery & Medicine; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56663