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Pallasch, Christian P. ORCID: 0000-0001-5675-6905 (2021). Cell cycle control in Richter transformation. Blood, 138 (12). S. 1005 - 1008. WASHINGTON: AMER SOC HEMATOLOGY. ISSN 1528-0020

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Abstract

In this issue of Blood, Chakraborty et al report that alterations in the function of TP53 and the cell-cycle regulators CDKN2A/CDKN2B cooperate in Richter transformation (RT) of chronic lymphocytic leukemia (CLL).(1) RT is characterized by the development of an aggressive lymphoma from indolent CLL and occurs in 2% to 10% of CLL patients. It represents the most difficult therapeutic challenge in CLL despite the multitude of targeted therapies that are currently available. The estimated overall survival is currently only 3.3 months.(2,3) Several factors for the development of RT have been identified such as loss of TP53, NOTCH1 mutations, constitutively active AKT, stereotyped B-cell receptors, and, notably, disruptions of the cell-cycle regulators CDKN2A/B in about 30% of cases.(4,5) Because RT is the biggest unmet need for patients with CLL, it is of critical importance to functionally dissect risk factors for RT to provide novel approaches for therapy of RT.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pallasch, Christian P. UNSPECIFIED orcid.org/0000-0001-5675-6905 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-567516
DOI:	10.1182/blood.2021011648
Journal or Publication Title:	Blood
Volume:	138
Number:	12
Page Range:	S. 1005 - 1008
Date:	2021
Publisher:	AMER SOC HEMATOLOGY
Place of Publication:	WASHINGTON
ISSN:	1528-0020
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56751