Universität zu Köln

Schmidt, Cynthia, Baessler, Bettina, Nakhostin, Dominik, Das, Arijit ORCID: 0000-0002-1108-6052, Eberhard, Matthias, Alkadhi, Hatem and Euler, Andre ORCID: 0000-0001-5019-4585 (2021). Dual-Energy CT-Based Iodine Quantification in Liver Tumors - Impact of Scan-, Patient-, and Position-Related Factors. Acad. Radiol., 28 (6). S. 783 - 790. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1878-4046

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Abstract

Rationale and Objectives: To quantify the contribution of lesion location and patient positioning, dual-energy approach, patient size, and radiation dose to the error of dual-energy CT-based iodine quantification (DECT-IQ) in liver tumors. Materials and Methods: A phantom with four liver lesions (diameter 15 mm; iodine concentration 0-5 mgI/mL) and two sizes was used. One lesion emulated a subdiaphragmatic lesion. Both sizes were imaged in dual-energy mode on (1) a dual-source DECT (DS-DE) at 100/ Sn150 kV and (2) a single-source split-filter DECT (SF-DE) at AuSn120 kV at two radiation doses (8 and 12 mGy). Scans were performed at seven different vertical table positions (from -6 to + 6 cm from the gantry isocenter). Iodine concentration was repeatedly measured and absolute errors (error(abs)) were calculated. Errors were compared using robust repeated-measures ANOVAs with post-hoc comparisons. A linear mixed effect model was used to determine the factors influencing the error of DECT-IQ. Results: The linear mixed effect models showed that errors were significantly influenced by DECT approach, phantom size, and lesion location (all p < 0.001). The impact of lesion location on the error was stronger in SF-DE compared to DS-DE. Radiation dose did not significantly influence error (p = 0.22). When averaged across all setups, error(abs) was significantly higher for SF-DE (2.08 +/- 1.92 mgI/mL) compared to DS-DE (0.37 +/- 0.29 mgI/mL) (all p < 0.001). Artefacts were found in the subdiaphragmatic lesion for SF-DE with significantly increased error(abs) compared to DS-DE (p < 0.001). Error(abs) was significantly higher in the large compared to the medium phantom for DS-DE (0.30 +/- 0.23 mgI/mL vs. 0.43 +/- 0.33 mgI/mL) and SF-DE (1.68 +/- 1.99 vs. 2.36 +/- 1.81 mgI/mL) (p < 0.001). Conclusion: The dual-energy approach, patient size, and lesion location modified by patient position significantly impacted DECT-IQ in simulated liver tumors.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schmidt, Cynthia UNSPECIFIED UNSPECIFIED UNSPECIFIED Baessler, Bettina UNSPECIFIED UNSPECIFIED UNSPECIFIED Nakhostin, Dominik UNSPECIFIED UNSPECIFIED UNSPECIFIED Das, Arijit UNSPECIFIED orcid.org/0000-0002-1108-6052 UNSPECIFIED Eberhard, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Alkadhi, Hatem UNSPECIFIED UNSPECIFIED UNSPECIFIED Euler, Andre UNSPECIFIED orcid.org/0000-0001-5019-4585 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-569925
DOI:	10.1016/j.acra.2020.04.021
Journal or Publication Title:	Acad. Radiol.
Volume:	28
Number:	6
Page Range:	S. 783 - 790
Date:	2021
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1878-4046
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RENAL-CELL CARCINOMA; IMAGE NOISE; CLEAR-CELL; CONTRAST; ATTENUATION; EXPERIENCE; ACCURACY; PHANTOM; MASSES Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56992