Universität zu Köln

Nettekoven, Charlotte, Pieczewski, Julia, Neuschmelting, Volker, Jonas, Kristina ORCID: 0000-0002-1067-9139, Goldbrunner, Roland, Grefkes, Christian ORCID: 0000-0002-1656-720X and Weiss Lucas, Carolin ORCID: 0000-0001-6463-0034 (2021). Improving the efficacy and reliability of rTMS language mapping by increasing the stimulation frequency. Hum. Brain Mapp., 42 (16). S. 5309 - 5322. HOBOKEN: WILEY. ISSN 1097-0193

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Abstract

Repetitive TMS (rTMS) with a frequency of 5-10 Hz is widely used for language mapping. However, it may be accompanied by discomfort and is limited in the number and reliability of evoked language errors. We, here, systematically tested the influence of different stimulation frequencies (i.e., 10, 30, and 50 Hz) on tolerability, number, reliability, and cortical distribution of language errors aiming at improved language mapping. 15 right-handed, healthy subjects (m = 8, median age: 29 yrs) were investigated in two sessions, separated by 2-5 days. In each session, 10, 30, and 50 Hz rTMS were applied over the left hemisphere in a randomized order during a picture naming task. Overall, 30 Hz rTMS evoked significantly more errors (20 +/- 12%) compared to 50 Hz (12 +/- 8%; p <.01), whereas error rates were comparable between 30/50 and 10 Hz (18 +/- 11%). Across all conditions, a significantly higher error rate was found in Session 1 (19 +/- 13%) compared to Session 2 (13 +/- 7%, p <.05). The error rate was poorly reliable between sessions for 10 (intraclass correlation coefficient, ICC = .315) and 30 Hz (ICC = .427), whereas 50 Hz showed a moderate reliability (ICC = .597). Spatial reliability of language errors was low to moderate with a tendency toward increased reliability for higher frequencies, for example, within frontal regions. Compared to 10 Hz, both, 30 and 50 Hz were rated as less painful. Taken together, our data favor the use of rTMS-protocols employing higher frequencies for evoking language errors reliably and with reduced discomfort, depending on the region of interest.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Nettekoven, Charlotte UNSPECIFIED UNSPECIFIED UNSPECIFIED Pieczewski, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Neuschmelting, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Jonas, Kristina UNSPECIFIED orcid.org/0000-0002-1067-9139 UNSPECIFIED Goldbrunner, Roland UNSPECIFIED UNSPECIFIED UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED Weiss Lucas, Carolin UNSPECIFIED orcid.org/0000-0001-6463-0034 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-570152
DOI:	10.1002/hbm.25619
Journal or Publication Title:	Hum. Brain Mapp.
Volume:	42
Number:	16
Page Range:	S. 5309 - 5322
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0193
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSCRANIAL MAGNETIC STIMULATION; CORTICAL STIMULATION; NAVIGATED TMS; UNCINATE FASCICULUS; FUNCTIONAL MRI; NAMING ERRORS; SPEECH; SAFETY; MOTOR; TOLERABILITY Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57015