Universität zu Köln

He, F., Steige, K. A., Kovacova, V, Goebel, U., Bouzid, M., Keightley, P. D., Beyer, A. and de Meaux, J. (2021). Cis-regulatory evolution spotlights species differences in the adaptive potential of gene expression plasticity. Nat. Commun., 12 (1). BERLIN: NATURE PORTFOLIO. ISSN 2041-1723

Full text not available from this repository.

Abstract

Phenotypic plasticity is the variation in phenotype that a single genotype can produce in different environments and, as such, is an important component of individual fitness. However, whether the effect of new mutations, and hence evolution, depends on the direction of plasticity remains controversial. Here, we identify the cis-acting modifications that have reshaped gene expression in response to dehydration stress in three Arabidopsis species. Our study shows that the direction of effects of most cis-regulatory variants differentiating the response between A. thaliana and the sister species A. lyrata and A. halleri depends on the direction of pre-existing plasticity in gene expression. A comparison of the rate of cis-acting variant accumulation in each lineage indicates that the selective forces driving adaptive evolution in gene expression favors regulatory changes that magnify the stress response in A. lyrata. The evolutionary constraints measured on the amino-acid sequence of these genes support this interpretation. In contrast, regulatory changes that mitigate the plastic response to stress evolved more frequently in A. halleri. Our results demonstrate that pre-existing plasticity may be a stepping stone for adaptation, but its selective remodeling differs between lineages. Plasticity allows organisms to respond to environmental change. Here the authors compare the distribution of cis-regulatory variants in the transcriptomes of Arabidopsis lyrata and A. halleriafter exposure to stress, to trace the role of polygenic selection in the evolution of gene expression plasticity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code He, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Steige, K. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kovacova, V UNSPECIFIED UNSPECIFIED UNSPECIFIED Goebel, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bouzid, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Keightley, P. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Beyer, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED de Meaux, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-570490
DOI:	10.1038/s41467-021-23558-2
Journal or Publication Title:	Nat. Commun.
Volume:	12
Number:	1
Date:	2021
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	2041-1723
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PHENOTYPIC PLASTICITY; ARABIDOPSIS; ADAPTATION; STRESS; SELECTION; ASSIMILATION; POLYMORPHISM; POPULATIONS; DIVERGENCE; PATTERN Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57049