Universität zu Köln

Lucassen, K., Gerson, S., Xanthopoulou, K., Wille, J., Wille, T., Seifert, H. and Higgins, P. G. (2021). Comparison of the Acinetobacter baumannii Reference Strains ATCC 17978 and ATCC 19606 in Antimicrobial Resistance Mediated by the AdeABC Efflux Pump. Antimicrob. Agents Chemother., 65 (8). WASHINGTON: AMER SOC MICROBIOLOGY. ISSN 1098-6596

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Abstract

The Acinetobacter baumannii RND efflux pump AdeABC is regulated by the 2-component regulator AdeRS. In this study, we compared the regulation and expression of AdeABC of the reference strains ATCC 17978 and ATCC 19606. A clearly stronger efflux activity was demonstrated for ATCC 19606. An amino acid substitution at residue 172 of adeS was identified as a potential cause for differential expression of the pump. Therefore, we recommend caution with exclusively using single reference strains for research.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lucassen, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gerson, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Xanthopoulou, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wille, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wille, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Seifert, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Higgins, P. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-571958
DOI:	10.1128/AAC.00570-21
Journal or Publication Title:	Antimicrob. Agents Chemother.
Volume:	65
Number:	8
Date:	2021
Publisher:	AMER SOC MICROBIOLOGY
Place of Publication:	WASHINGTON
ISSN:	1098-6596
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SUSCEPTIBILITY; SUBSTITUTION; TIGECYCLINE; EXPRESSION; ADER Multiple languages Microbiology; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57195