Universität zu Köln

Thevis, Mario, Piper, Thomas and Thomas, Andreas (2021). Recent advances in identifying and utilizing metabolites of selected doping agents in human sports drug testing. J. Pharm. Biomed. Anal., 205. AMSTERDAM: ELSEVIER. ISSN 1873-264X

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Abstract

Probing for evidence of the administration of prohibited therapeutics, drugs and/or drug candidates as well as the use of methods of doping in doping control samples is a central assignment of anti-doping laboratories. In order to accomplish the desired analytical sensitivity, retrospectivity, and comprehensiveness, a considerable portion of anti-doping research has been invested into studying metabolic biotransformation and elimination profiles of doping agents. As these doping agents include lower molecular mass drugs such as e.g. stimulants and anabolic androgenic steroids, some of which further necessitate the differentiation of their natural/endogenous or xenobiotic origin, but also higher molecular mass substances such as e.g. insulins, growth hormone, or siRNA/anti-sense oligonucleotides, a variety of different strategies towards the identification of employable and informative metabolites have been developed. In this review, approaches supporting the identification, characterization, and implementation of metabolites exemplified by means of selected doping agents into routine doping controls are presented, and challenges as well as solutions reported and published between 2010 and 2020 are discussed. (c) 2021 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Thevis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Piper, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomas, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-572017
DOI:	10.1016/j.jpba.2021.114312
Journal or Publication Title:	J. Pharm. Biomed. Anal.
Volume:	205
Date:	2021
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1873-264X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANDROGEN RECEPTOR MODULATOR; TANDEM MASS-SPECTROMETRY; IN-VITRO METABOLISM; PEPTIDES LESS-THAN-2 KDA; LIQUID-CHROMATOGRAPHY; HUMAN URINE; HIGH-RESOLUTION; ISOTOPE-RATIO; GENERATED METABOLITES; SULFATE METABOLITES Multiple languages Chemistry, Analytical; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57201