Universität zu Köln

Puladi, Behrus ORCID: 0000-0001-5909-6105, Dinekov, Maja, Arzberger, Thomas, Taubert, Max and Kohler, Christoph (2021). The relation between tau pathology and granulovacuolar degeneration of neurons. Neurobiol. Dis., 147. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-953X

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Abstract

Neurofibrillary tangles arising from aggregated microtubule-associated protein tau occur in aged brains and are hallmarks of neurodegenerative diseases. A subset of neurons containing aggregated tau displays granulovacuolar degeneration (GVD) that is characterized by membrane-bound cytoplasmic vacuoles, each containing an electron dense granule (GVB). Tau pathology induces GVBs in experimental models, but GVD does not generally follow tau pathology in the human brain. The entorhinal cortex, DRN, and LC are among the regions that display pathological changes of tau earliest, whereas neurons with GVBs occur first in the hippocampus and have been found in oral raphe nuclei only at the most advanced GVD stage. To date, there is no detailed report about neurons with GVD in aminergic nuclei. We studied the relation between tau pathology and GVD in field CA1 of the hippocampus, entorhinal cortex, dorsal (DRN) and median (MRN) raphe nucleus, and locus coeruleus from elderly subjects with Braak & Braak stages of tau pathology ranging from 0 to VI. Tau pathology and GVBs were visualized by means of immunolabeling and quantified. Percentages of neurons containing GVBs were significantly related to percentages of AT8-positive neurons in the regions examined. GVD and tau pathology were found together in neurons to a different extent in regions of the brain. 53.2% of AT8-immunoreactive neurons in CA1, 19.8% in layer II of the entorhinal cortex, 29.6% in the DRN, and 31.4% in the locus coeruleus contained GVBs. Age-related factors, the percentage of neurons with pretangles in a region of the brain, and the metabolism of a neuron possibly influence the prevalence of neurons with GVBs.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Puladi, Behrus UNSPECIFIED orcid.org/0000-0001-5909-6105 UNSPECIFIED Dinekov, Maja UNSPECIFIED UNSPECIFIED UNSPECIFIED Arzberger, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Taubert, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Kohler, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-573225
DOI:	10.1016/j.nbd.2020.105138
Journal or Publication Title:	Neurobiol. Dis.
Volume:	147
Date:	2021
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-953X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UNFOLDED PROTEIN RESPONSE; GLYCOGEN-SYNTHASE KINASE-3; ENTORHINAL CORTEX NEURONS; HUMAN LOCUS-COERULEUS; ALZHEIMERS-DISEASE; NEUROFIBRILLARY TANGLES; HIPPOCAMPAL CORTEX; DEMENTED PATIENTS; CONGO RED; 1 DELTA Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57322