Bebber, Christina M. and von Karstedt, Silvia (2021). Non-neuroendocrine differentiation generates a ferroptosis-prone lipidome in small cell lung cancer (SCLC). MOL. CELL ONCOL., 8 (4). PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 2372-3556
Full text not available from this repository.Abstract
Our recent study revealed that non-neuroendocrine small cell lung cancer (SCLC) is sensitive to the induction of ferroptosis due to upregulation of ether lipid synthesis. While neuroendocrine SCLC is ferroptosis resistant, it acquires addiction to the thioredoxin pathway. Combined redox pathway targeting therefore achieves efficient anti-tumor activity in heterogenous SCLC.
| Item Type: | Journal Article | ||||||||||||
| Creators: |
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| URN: | urn:nbn:de:hbz:38-574330 | ||||||||||||
| DOI: | 10.1080/23723556.2021.1933871 | ||||||||||||
| Journal or Publication Title: | MOL. CELL ONCOL. | ||||||||||||
| Volume: | 8 | ||||||||||||
| Number: | 4 | ||||||||||||
| Date: | 2021 | ||||||||||||
| Publisher: | TAYLOR & FRANCIS INC | ||||||||||||
| Place of Publication: | PHILADELPHIA | ||||||||||||
| ISSN: | 2372-3556 | ||||||||||||
| Language: | English | ||||||||||||
| Faculty: | Unspecified | ||||||||||||
| Divisions: | Unspecified | ||||||||||||
| Subjects: | no entry | ||||||||||||
| Uncontrolled Keywords: |
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| URI: | http://kups.ub.uni-koeln.de/id/eprint/57433 |
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