Bebber, Christina M. and von Karstedt, Silvia (2021). Non-neuroendocrine differentiation generates a ferroptosis-prone lipidome in small cell lung cancer (SCLC). MOL. CELL ONCOL., 8 (4). PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 2372-3556

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Abstract

Our recent study revealed that non-neuroendocrine small cell lung cancer (SCLC) is sensitive to the induction of ferroptosis due to upregulation of ether lipid synthesis. While neuroendocrine SCLC is ferroptosis resistant, it acquires addiction to the thioredoxin pathway. Combined redox pathway targeting therefore achieves efficient anti-tumor activity in heterogenous SCLC.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bebber, Christina M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Karstedt, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-574330
DOI: 10.1080/23723556.2021.1933871
Journal or Publication Title: MOL. CELL ONCOL.
Volume: 8
Number: 4
Date: 2021
Publisher: TAYLOR & FRANCIS INC
Place of Publication: PHILADELPHIA
ISSN: 2372-3556
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/57433

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