Hopff, Sina M., Onambele, Liliane A., Brandenburg, Marc, Berkessel, Albrecht and Prokop, Aram (2021). Sensitizing multidrug-resistant leukemia cells to common cytostatics by an aluminium-salen complex that has high-apoptotic effects in leukemia, lymphoma and mamma carcinoma cells. Biometals, 34 (2). S. 211 - 221. DORDRECHT: SPRINGER. ISSN 1572-8773

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Abstract

We investigated the aluminium-salen complex MBR-8 as a potential anti-cancer agent. To see apoptotic effects induced by MBR-8, alone and in combination with common cytostatic drugs, DNA-fragmentations were studied using the flow cytometric analysis. Western blot analysis and measurement of the mitochondrial membrane potential with a JC-1 dye were employed to identify the pathway of apoptosis. An impressive overcoming of multidrug-resistance in leukemia (Nalm6) cells was observed. Additionally, solid tumor cells including Burkitt-like lymphoma (BJAB) and mamma carcinoma cells (MCF-7) are affected by MBR-8 in the same way. Western blot analysis revealed activation of caspase-3. MBR-8 showed very pronounced selectivity with regard to tumor cells and high synergistic effects in Nalm6 and daunorubicin-resistant Nalm6 cells when administered in combination with vincristine, daunorubicin and doxorubicin. The aluminium-salen complex MBR-8 showed very promising anti-cancer properties which warrant further development towards a cytostatic agent for future chemotherapy. Studies on aluminium compounds for cancer therapy are rare, and our report adds to this important body of knowledge.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hopff, Sina M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Onambele, Liliane A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brandenburg, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berkessel, AlbrechtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prokop, AramUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-575080
DOI: 10.1007/s10534-020-00273-x
Journal or Publication Title: Biometals
Volume: 34
Number: 2
Page Range: S. 211 - 221
Date: 2021
Publisher: SPRINGER
Place of Publication: DORDRECHT
ISSN: 1572-8773
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Biochemistry & Molecular BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/57508

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