Franklin, Cindy ORCID: 0000-0001-9142-5423, Wetter, Axel, Baba, Hideo Andreas, Theysohn, Jens, Haubold, Johannes, Cosgarea, Ioana, Hadaschik, Eva, Livingstone, Elisabeth ORCID: 0000-0001-8279-9239, Zimmer, Lisa ORCID: 0000-0002-3680-3521, Stoffels, Ingo, Klode, Joachim, Lodde, Georg, Placke, Jan-Malte, Schadendorf, Dirk and Ugurel, Selma (2021). Computed tomography-guided biopsy of radiologically unclear lesions in advanced skin cancer: A retrospective analysis of 47 cases. Eur. J. Cancer, 150. S. 119 - 130. OXFORD: ELSEVIER SCI LTD. ISSN 1879-0852

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Abstract

Background: Radiological imaging such as computed tomography (CT) is used frequently for disease staging and therapy monitoring in advanced skin cancer patients. Detected lesions of unclear dignity are a common challenge for treating physicians. The aim of this study was to assess the frequency and outcome of CT-guided biopsy (CTGB) of radiologically unclear, suspicious lesions and to depict its usefulness in different clinical settings. Methods: This retrospective monocentric study included advanced skin cancer patients (melanoma, Merkel cell carcinoma, squamous cell carcinoma, angiosarcoma, cutaneous lymphoma) with radiologically unclear lesions who underwent CTGB between 2010 and 2018. Results: Of 59 skin cancer patients who received CTGB, 47 received CTGB to clarify radio logically suspicious lesions of unclear dignity. 32 patients had no systemic therapy (cohort A), while 15 patients received systemic treatment at CTGB (cohort B). In both cohorts, CTGB revealed skin cancer metastasis in a large proportion of patients (37.5%, 40.0%, respectively), but benign tissue showing inflammation, fibrosis or infection in an equally large percentage (37.5%, 46.7%, respectively). Additionally, a significant number of other cancer entities was found (25.0%, 13.3%, respectively). In patients receiving BRAF/MEK inhibitors, CTGB confirmed suspicious lesions as skin cancer metastasis in 83.3%, leading to treatment change. In immune checkpoint inhibitor-treated patients, skin cancer metastasis was confirmed in 11.1% of patients only, whereas benign tissue changes (inflammation/fibrosis) were found in 77.8%. Conclusions: Our results highlight the relevance of clarifying radiologically unclear lesions by CTGB before start or change of an anti-tumour therapy to exclude benign alterations and secondary malignancies. (c)& nbsp;2021 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Franklin, CindyUNSPECIFIEDorcid.org/0000-0001-9142-5423UNSPECIFIED
Wetter, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baba, Hideo AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Theysohn, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haubold, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cosgarea, IoanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hadaschik, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Livingstone, ElisabethUNSPECIFIEDorcid.org/0000-0001-8279-9239UNSPECIFIED
Zimmer, LisaUNSPECIFIEDorcid.org/0000-0002-3680-3521UNSPECIFIED
Stoffels, IngoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klode, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lodde, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Placke, Jan-MalteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schadendorf, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ugurel, SelmaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-575259
DOI: 10.1016/j.ejca.2021.03.026
Journal or Publication Title: Eur. J. Cancer
Volume: 150
Page Range: S. 119 - 130
Date: 2021
Publisher: ELSEVIER SCI LTD
Place of Publication: OXFORD
ISSN: 1879-0852
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
POSITRON-EMISSION-TOMOGRAPHY; MELANOMA PATIENTS; NEEDLE-BIOPSY; METASTATIC MELANOMA; FOLLOW-UP; LUNG-BIOPSY; RISK; DIAGNOSIS; COMPLICATIONS; PNEUMOTHORAXMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/57525

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