Universität zu Köln

Kaur, Jasleen, Arroub, Karim, Drzezga, Alexander, Schomaecker, Klaus and Mathur, Sanjay (2021). Synthesis, proteolytic stability, and in vitro evaluation of DOTA conjugated p160 peptide based radioconjugates: [Lu-177]Lu-DOTA-p160. Org. Biomol. Chem., 19 (45). S. 9849 - 9855. CAMBRIDGE: ROYAL SOC CHEMISTRY. ISSN 1477-0539

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Abstract

In this work, we describe the synthesis, in vitro stability, and preliminary biological evaluation of [Lu-177]Lu-DOTA-p160 peptide-based radiopharmaceuticals. Our findings highlight that all DOTA-p160-peptide radioconjugates exhibit favorable proteolytic and enzymatic stability with a prolonged half-life in human plasma and serum. Cell uptake studies carried out on MCF-7 cell line revealed saturable binding of the radioconjugates in the nanomolar range, thereby demonstrating their promising potential in the imaging and therapy of breast tumors.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kaur, Jasleen UNSPECIFIED UNSPECIFIED UNSPECIFIED Arroub, Karim UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Schomaecker, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathur, Sanjay UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-575408
DOI:	10.1039/d1ob01812d
Journal or Publication Title:	Org. Biomol. Chem.
Volume:	19
Number:	45
Page Range:	S. 9849 - 9855
Date:	2021
Publisher:	ROYAL SOC CHEMISTRY
Place of Publication:	CAMBRIDGE
ISSN:	1477-0539
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BREAST-CANCER Multiple languages Chemistry, Organic Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57540