Universität zu Köln

Butt, Linus, Unnersjoe-Jess, David, Hoehne, Martin, Schermer, Bernhard, Edwards, Aurelie and Benzing, Thomas (2021). A mathematical estimation of the physical forces driving podocyte detachment. Kidney Int., 100 (5). S. 1054 - 1063. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1523-1755

Full text not available from this repository.

Abstract

Loss of podocytes, possibly through the detachment of viable cells, is a hallmark of progressive glomerular disease. Podocytes are exposed to considerable physical forces due to pressure and flow resulting in circumferential wall stress and tangential shear stress exerted on the podocyte cell body, which have been proposed to contribute to podocyte depletion. However, estimations of in vivo alterations of physical forces in glomerular disease have been hampered by a lack of quantitative functional and morphological data. Here, we used ultra-resolution data and computational analyses in a mouse model of human disease, hereditary late-onset focal segmental glomerular sclerosis, to calculate increased mechanical stress upon podocyte injury. Transversal shear stress on the lateral walls of the foot processes was prominently increased during the initial stages of podocyte detachment. Thus, our study highlights the importance of targeting glomerular hemodynamics to treat glomerular disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Butt, Linus UNSPECIFIED UNSPECIFIED UNSPECIFIED Unnersjoe-Jess, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoehne, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Schermer, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Edwards, Aurelie UNSPECIFIED UNSPECIFIED UNSPECIFIED Benzing, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-575900
DOI:	10.1016/j.kint.2021.06.040
Journal or Publication Title:	Kidney Int.
Volume:	100
Number:	5
Page Range:	S. 1054 - 1063
Date:	2021
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1523-1755
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GLOMERULAR-BASEMENT-MEMBRANE; MECHANICAL FORCES; ANGIOTENSIN-II; DEPLETION; GLOMERULOSCLEROSIS; NEPHROPATHY; PRESSURE; INTEGRIN; MUTATION; BARRIER Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57590