Universität zu Köln

Quaas, Alexander, Pamuk, Aylin, Klein, Sebastian ORCID: 0000-0002-2188-9377, Quantius, Jennifer, Rehkaemper, Jan, Barutcu, Atakan G., Rueschoff, Josef, Zander, Thomas, Gebauer, Florian, Hillmer, Axel, Buettner, Reinhard, Schroeder, Wolfgang, Bruns, Christiane J., Loeser, Heike, Schoemig-Markiefka, Birgid and Alakus, Hakan (2021). Sex-specific prognostic effect of CD66b-positive tumor-infiltrating neutrophils (TANs) in gastric and esophageal adenocarcinoma. Gastric Cancer, 24 (6). S. 1213 - 1227. NEW YORK: SPRINGER. ISSN 1436-3305

Full text not available from this repository.

Abstract

Background Tumor-associated neutrophils (TANs) have recently been identified as a relevant component of the tumor microenvironment (TME) in solid tumors. Within the TME TANs mediate either tumor-promoting or tumor-inhibiting activities. So far, their prognostic relevance remains to be determined. This study aims to evaluate the prognostic relevance of TANs in different molecular subtypes of gastric and esophageal adenocarcinoma. Methods We analyzed a total of 1118 Caucasian patients divided into gastric adenocarcinoma (n = 458) and esophageal adenocarcinoma cohort (n = 660) of primarily resected and neoadjuvant-treated individuals. The amount of CD66b + TANs in the tumor stroma was determined using quantitative image analysis and correlated to both molecular, as well as clinical data. Results An accumulation of TANs in the tumor stroma of gastric carcinomas was associated to a significant favorable prognosis (p = 0.026). A subgroup analysis showed that this effect was primarily related to the molecular chromosomal instable subtype (CIN) of gastric carcinomas (p = 0.010). This was only observed in female patients (p = 0.014) but not in male patients (p = 0.315). The same sex-specific effect could be confirmed in adenocarcinomas of the esophagus (p = 0.027), as well as in female individuals after receiving neoadjuvant therapy (p = 0.034). Conclusions Together, we show a sex-specific prognostic effect of TANs in gastric cancer within a Caucasian cohort. For the first time, we showed that this sex-specific prognostic effect of TANs can also be seen in esophageal cancer.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Quaas, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Pamuk, Aylin UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Sebastian UNSPECIFIED orcid.org/0000-0002-2188-9377 UNSPECIFIED Quantius, Jennifer UNSPECIFIED UNSPECIFIED UNSPECIFIED Rehkaemper, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Barutcu, Atakan G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rueschoff, Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED Zander, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Gebauer, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Hillmer, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeder, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruns, Christiane J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Loeser, Heike UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoemig-Markiefka, Birgid UNSPECIFIED UNSPECIFIED UNSPECIFIED Alakus, Hakan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-576245
DOI:	10.1007/s10120-021-01197-2
Journal or Publication Title:	Gastric Cancer
Volume:	24
Number:	6
Page Range:	S. 1213 - 1227
Date:	2021
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1436-3305
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CANCER Multiple languages Oncology; Gastroenterology & Hepatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57624