Universität zu Köln

Sawant, Mugdha, Hinz, Boris, Schonborn, Katrin, Zeinert, Isabel, Eckes, Beate, Krieg, Thomas and Schuster, Ronen ORCID: 0000-0002-8640-4692 (2021). A story of fibers and stress: Matrix-embedded signals for fibroblast activation in the skin. Wound Repair Regen., 29 (4). S. 515 - 531. HOBOKEN: WILEY. ISSN 1524-475X

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Abstract

Our skin is continuously exposed to mechanical challenge, including shear, stretch, and compression. The extracellular matrix of the dermis is perfectly suited to resist these challenges and maintain integrity of normal skin even upon large strains. Fibroblasts are the key cells that interpret mechanical and chemical cues in their environment to turnover matrix and maintain homeostasis in the skin of healthy adults. Upon tissue injury, fibroblasts and an exclusive selection of other cells become activated into myofibroblasts with the task to restore skin integrity by forming structurally imperfect but mechanically stable scar tissue. Failure of myofibroblasts to terminate their actions after successful repair or upon chronic inflammation results in dysregulated myofibroblast activities which can lead to hypertrophic scarring and/or skin fibrosis. After providing an overview on the major fibrillar matrix components in normal skin, we will interrogate the various origins of fibroblasts and myofibroblasts in the skin. We then examine the role of the matrix as signaling hub and how fibroblasts respond to mechanical matrix cues to restore order in the confusing environment of a healing wound.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sawant, Mugdha UNSPECIFIED UNSPECIFIED UNSPECIFIED Hinz, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Schonborn, Katrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Zeinert, Isabel UNSPECIFIED UNSPECIFIED UNSPECIFIED Eckes, Beate UNSPECIFIED UNSPECIFIED UNSPECIFIED Krieg, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuster, Ronen UNSPECIFIED orcid.org/0000-0002-8640-4692 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-576590
DOI:	10.1111/wrr.12950
Journal or Publication Title:	Wound Repair Regen.
Volume:	29
Number:	4
Page Range:	S. 515 - 531
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1524-475X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DOMAIN RECEPTOR 1; INTEGRIN-LINKED KINASE; SMOOTH MUSCLE ACTIN; EXTRACELLULAR-MATRIX; HAIR-FOLLICLE; TGF-BETA; GRANULATION-TISSUE; COLLAGEN-XII; MYOFIBROBLAST DIFFERENTIATION; PULMONARY-FIBROSIS Multiple languages Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57659