Wolff, Lisa ORCID: 0000-0002-7296-0479, Strathmann, Eike A., Mueller, Ilka, Maehlich, Daniela, Veltman, Charlotte, Niehoff, Anja and Wirth, Brunhilde ORCID: 0000-0003-4051-5191 (2021). Plastin 3 in health and disease: a matter of balance. Cell. Mol. Life Sci., 78 (13). S. 5275 - 5302. BASEL: SPRINGER BASEL AG. ISSN 1420-9071
Full text not available from this repository.Abstract
For a long time, PLS3 (plastin 3, also known as T-plastin or fimbrin) has been considered a rather inconspicuous protein, involved in F-actin-binding and -bundling. However, in recent years, a plethora of discoveries have turned PLS3 into a highly interesting protein involved in many cellular processes, signaling pathways, and diseases. PLS3 is localized on the X-chromosome, but shows sex-specific, inter-individual and tissue-specific expression variability pointing towards skewed X-inactivation. PLS3 is expressed in all solid tissues but usually not in hematopoietic cells. When escaping X-inactivation, PLS3 triggers a plethora of different types of cancers. Elevated PLS3 levels are considered a prognostic biomarker for cancer and refractory response to therapies. When it is knocked out or mutated in humans and mice, it causes osteoporosis with bone fractures; it is the only protein involved in actin dynamics responsible for osteoporosis. Instead, when PLS3 is upregulated, it acts as a highly protective SMN-independent modifier in spinal muscular atrophy (SMA). Here, it seems to counteract reduced F-actin levels by restoring impaired endocytosis and disturbed calcium homeostasis caused by reduced SMN levels. In contrast, an upregulation of PLS3 on wild-type level might cause osteoarthritis. This emphasizes that the amount of PLS3 in our cells must be precisely balanced; both too much and too little can be detrimental. Actin-dynamics, regulated by PLS3 among others, are crucial in a lot of cellular processes including endocytosis, cell migration, axonal growth, neurotransmission, translation, and others. Also, PLS3 levels influence the infection with different bacteria, mycosis, and other pathogens.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-576840 | ||||||||||||||||||||||||||||||||
DOI: | 10.1007/s00018-021-03843-5 | ||||||||||||||||||||||||||||||||
Journal or Publication Title: | Cell. Mol. Life Sci. | ||||||||||||||||||||||||||||||||
Volume: | 78 | ||||||||||||||||||||||||||||||||
Number: | 13 | ||||||||||||||||||||||||||||||||
Page Range: | S. 5275 - 5302 | ||||||||||||||||||||||||||||||||
Date: | 2021 | ||||||||||||||||||||||||||||||||
Publisher: | SPRINGER BASEL AG | ||||||||||||||||||||||||||||||||
Place of Publication: | BASEL | ||||||||||||||||||||||||||||||||
ISSN: | 1420-9071 | ||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/57684 |
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