Universität zu Köln

Langenbach, Marcel C., Vogl, Thomas J., Said, Gulia, Scholtz, Jan-Erik, Hammerstingl, Renate and Gruber-Rouh, Tatjana . Lipiodol as a Predictive Indicator for Therapy Response to Transarterial Chemoembolization of Hepatocellular Carcinoma. Cancer Biother. Radiopharm.. NEW ROCHELLE: MARY ANN LIEBERT, INC. ISSN 1557-8852

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Abstract

Background: To evaluate the predictive value of Lipiodol for response evaluation of hepatocellular carcinoma (HCC) treated with conventional transarterial chemoembolization (cTACE) by analysis of the enhancement pattern during angiography and in postinterventional computed tomography (CT). Materials and Methods: This retrospective study included 30 patients (mean age 63 years, range: 36 to 82 years, 22 males) with HCC. Patients received three Lipiodol-based cTACE sessions, each followed by an unenhanced CT within 24-h. Contrast-enhanced magnetic resonance imaging (MRI) was acquired before and after the treatment to determine tumor response. Lipiodol enhancement pattern, tumor vascularization, and density were evaluated by angiography and CT. Initial tumor size and response to cTACE were analyzed by MRI according to modified response evaluation criteria in solid tumors (mRECIST) in a 4-week follow-up. Results: Analysis of HCC lesions (68 lesions in 30 patients) during cTACE revealed clear visibility and hypervascularization in angiography as a potential independent parameter able to predict tumor response. A significant correlation was found for response measurements by volume (p = 0.012), diameter (p = 0.006), and according to mRECIST (p = 0.039). The amount of Lipiodol and enhancement pattern in postinterventional CT did not correlate with therapy response. Measurements of Hounsfield unit values after cTACE do not allow sufficient prediction of the tumor response. Conclusion: Hypervascularized HCC lesions with clear visibility after Lipiodol administration in the angiography respond significantly better to cTACE compared to hypo- or nonvascularized lesions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Langenbach, Marcel C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vogl, Thomas J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Said, Gulia UNSPECIFIED UNSPECIFIED UNSPECIFIED Scholtz, Jan-Erik UNSPECIFIED UNSPECIFIED UNSPECIFIED Hammerstingl, Renate UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruber-Rouh, Tatjana UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-577178
DOI:	10.1089/cbr.2020.4137
Journal or Publication Title:	Cancer Biother. Radiopharm.
Publisher:	MARY ANN LIEBERT, INC
Place of Publication:	NEW ROCHELLE
ISSN:	1557-8852
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION; EVALUATION CRITERIA; MULTIDETECTOR CT; LIVER; TACE; MRECIST; TUMORS; OIL; PROGRESSION; SYSTEM Multiple languages Oncology; Medicine, Research & Experimental; Pharmacology & Pharmacy; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57717