Universität zu Köln

Osae, Eugene Appenteng and Steven, Philipp ORCID: 0000-0001-6892-3619 (2021). Meibomian Gland Dysfunction in Ocular Graft vs. Host Disease: A Need for Pre-Clinical Models and Deeper Insights. Int. J. Mol. Sci., 22 (7). BASEL: MDPI. ISSN 1422-0067

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Abstract

Despite decades of experience with hematopoietic stem cell transplantation, we are still faced with the delicate equipoise of achieving stable ocular health post-transplantation. This is because ocular graft-versus-host disease (oGvHD) following hematopoietic stem cell transplantation frequently occurs (>= 50%) among transplant patients. To date, our understanding of the pathophysiology of oGvHD especially the involvement of the meibomian gland is still limited as a result of a lack of suitable preclinical models among other. Herein, the current state of the etiology and, pathophysiology of oGvHD based on existing pre-clinical models are reviewed. The need for additional pre-clinical models and knowledge about the involvement of the meibomian glands in oGvHD are emphasized.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Osae, Eugene Appenteng UNSPECIFIED UNSPECIFIED UNSPECIFIED Steven, Philipp UNSPECIFIED orcid.org/0000-0001-6892-3619 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-577642
DOI:	10.3390/ijms22073516
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	22
Number:	7
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANTATION; DRY EYE; TEAR FILM; INTERNATIONAL WORKSHOP; PATHOGENESIS; SUBCOMMITTEE; MANAGEMENT; SURFACE; STRESS Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57764