Osae, Eugene Appenteng and Steven, Philipp ORCID: 0000-0001-6892-3619
(2021).
Meibomian Gland Dysfunction in Ocular Graft vs. Host Disease: A Need for Pre-Clinical Models and Deeper Insights.
Int. J. Mol. Sci., 22 (7).
BASEL:
MDPI.
ISSN 1422-0067
Abstract
Despite decades of experience with hematopoietic stem cell transplantation, we are still faced with the delicate equipoise of achieving stable ocular health post-transplantation. This is because ocular graft-versus-host disease (oGvHD) following hematopoietic stem cell transplantation frequently occurs (>= 50%) among transplant patients. To date, our understanding of the pathophysiology of oGvHD especially the involvement of the meibomian gland is still limited as a result of a lack of suitable preclinical models among other. Herein, the current state of the etiology and, pathophysiology of oGvHD based on existing pre-clinical models are reviewed. The need for additional pre-clinical models and knowledge about the involvement of the meibomian glands in oGvHD are emphasized.
Item Type: | Journal Article | ||||||||||||
Creators: |
|
||||||||||||
URN: | urn:nbn:de:hbz:38-577642 | ||||||||||||
DOI: | 10.3390/ijms22073516 | ||||||||||||
Journal or Publication Title: | Int. J. Mol. Sci. | ||||||||||||
Volume: | 22 | ||||||||||||
Number: | 7 | ||||||||||||
Date: | 2021 | ||||||||||||
Publisher: | MDPI | ||||||||||||
Place of Publication: | BASEL | ||||||||||||
ISSN: | 1422-0067 | ||||||||||||
Language: | English | ||||||||||||
Faculty: | Unspecified | ||||||||||||
Divisions: | Unspecified | ||||||||||||
Subjects: | no entry | ||||||||||||
Uncontrolled Keywords: |
|
||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/57764 |
Downloads
Downloads per month over past year
Altmetric
Export
Actions (login required)
![]() |
View Item |