Universität zu Köln

Koksal, Muammer Osman, Yalcin, Basak Keskin, Keskin, Fahriye, Ciftci, Sevgi, Yagci, Ibrahim, Hascicek, Seyhan Ozakkoyunlu, Basaran, Bora, Deger, Kemal, Agacfidan, Ali, Quaas, Alexander and Akguel, Baki (2021). Genotype Distribution and Prevalence of Human Papillomavirus in Head and Neck Cancer Samples from Istanbul, Turkey. Pathogens, 10 (12). BASEL: MDPI. ISSN 2076-0817

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Abstract

Human papillomavirus (HPV)-associated tumors account for a significant proportion of head and neck squamous cell carcinomas (HNSCC) in developed countries. In recent years, there has been a rise of HPV infections associated with HNSCC, especially HPV16, which is the most commonly detected type in oral and oropharyngeal cancers. To investigate the frequency of HPV-driven HNSCC among patients living in Turkey, HPV DNA positivity and p16INK4A expression were assessed in primary tumor biopsies (n = 106). Eighteen out of one hundred and six (19%) HNSCC tumors showed p16INK4A overexpression, and 26/106 cases (24.5%) were positive for HPV DNA. Sixteen out of twenty-six samples were positive for both HPV DNA and p16INK4A staining. HPV16 could be isolated from 22/26 samples (84.6%) and was found to be the most frequently detected HPV type. This study represents the largest cohort of Turkish patients with HNSCC characterized according to HPV status and p16INK4A expression. Our data suggest that HPV16 infection, along with smoking, contribute to the development of HNSCC.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koksal, Muammer Osman UNSPECIFIED UNSPECIFIED UNSPECIFIED Yalcin, Basak Keskin UNSPECIFIED UNSPECIFIED UNSPECIFIED Keskin, Fahriye UNSPECIFIED UNSPECIFIED UNSPECIFIED Ciftci, Sevgi UNSPECIFIED UNSPECIFIED UNSPECIFIED Yagci, Ibrahim UNSPECIFIED UNSPECIFIED UNSPECIFIED Hascicek, Seyhan Ozakkoyunlu UNSPECIFIED UNSPECIFIED UNSPECIFIED Basaran, Bora UNSPECIFIED UNSPECIFIED UNSPECIFIED Deger, Kemal UNSPECIFIED UNSPECIFIED UNSPECIFIED Agacfidan, Ali UNSPECIFIED UNSPECIFIED UNSPECIFIED Quaas, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Akguel, Baki UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-579093
DOI:	10.3390/pathogens10121533
Journal or Publication Title:	Pathogens
Volume:	10
Number:	12
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-0817
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SQUAMOUS-CELL CARCINOMA; OROPHARYNGEAL CANCERS; VIRUS PREVALENCE; HPV DNA; P16; EPIDEMIOLOGY; METAANALYSIS; EXPRESSION; INFECTION; DIAGNOSIS Multiple languages Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57909