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Gehring, Niels H. and Roignant, Jean-Yves (2021). Anything but Ordinary - Emerging Splicing Mechanisms in Eukaryotic Gene Regulation. Trends Genet., 37 (4). S. 355 - 373. LONDON: ELSEVIER SCIENCE LONDON. ISSN 1362-4555

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Abstract

Splicing of precursor mRNAs (pre-mRNA) is an important step during eukaryotic gene expression. The identification of the actual splice sites and the proper removal of introns are essential for the production of the desired mRNA isoforms and their encoded proteins. While the basic mechanisms of splicing regulation are well understood, recent work has uncovered a growing number of noncanonical splicing mechanisms that play key roles in the regulation of gene expression. In this review, we summarize the current principles of splicing regulation, including the impact of cis and trans regulatory elements, as well as the influence of chromatin structure, transcription, and RNA modifications. We further discuss the recent development of emerging splicing mechanisms, such as recursive and back splicing, and their impact on gene expression.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gehring, Niels H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roignant, Jean-Yves UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-579831
DOI:	10.1016/j.tig.2020.10.008
Journal or Publication Title:	Trends Genet.
Volume:	37
Number:	4
Page Range:	S. 355 - 373
Date:	2021
Publisher:	ELSEVIER SCIENCE LONDON
Place of Publication:	LONDON
ISSN:	1362-4555
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57983