Universität zu Köln

Rosenbrock, Johannes, Baues, Christian, Vasquez-Torres, Andres, Clivio, Alessandro, Fogliata, Antonella, Borchmann, Peter, Marnitz, Simone and Cozzi, Luca (2022). Volumetric modulated arc therapy versus intensity-modulated proton therapy in the irradiation of infra diaphragmatic Hodgkin Lymphoma in female patients. Acta Oncol., 61 (1). S. 81 - 89. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1651-226X

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Abstract

Purpose To investigate the role of infra diaphragmatic intensity-modulated proton therapy (IMPT) compared to volumetric modulated arc therapy (VMAT) for female Hodgkin Lymphoma (HL) patients and to estimate the risk of secondary cancer and ovarian failure. Methods A comparative treatment planning study was performed on 14 patients, and the results were compared according to conventional dose-volume metrics. In addition, estimates of the excess absolute risk (EAR) of secondary cancer induction were determined for the bowel, the bladder and the rectum. For the ovaries, the risk of ovarian failure was estimated. Results The dosimetric findings demonstrate the equivalence between VMAT and IMPT in terms of target coverage. A statistically significant reduction of the mean and near-to-maximum doses was proven for the organs at risk. The EAR ratio estimated for IMPT to VMAT was 0.51 +/- 0.32, 0.32 +/- 0.35 and 0.05 +/- 0.11 for the bowel, bladder and rectum, respectively. Concerning the risk of ovarian failure for the chronologic age ranging from 18 to 46 years, the expected net loss in fertility years ranged from 4.8 to 3.0 years for protons and 12.0 to 5.7 years for photons. Conclusion This in-silico study confirmed the beneficial role of IMPT from a dosimetric point of view. Mathematical models suggested that the use of protons might be further advantageous due to the expected reduction of the risk of secondary cancer induction and its milder impact on the reduction of fertility.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rosenbrock, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Baues, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Vasquez-Torres, Andres UNSPECIFIED UNSPECIFIED UNSPECIFIED Clivio, Alessandro UNSPECIFIED UNSPECIFIED UNSPECIFIED Fogliata, Antonella UNSPECIFIED UNSPECIFIED UNSPECIFIED Borchmann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Marnitz, Simone UNSPECIFIED UNSPECIFIED UNSPECIFIED Cozzi, Luca UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-580594
DOI:	10.1080/0284186X.2021.1986230
Journal or Publication Title:	Acta Oncol.
Volume:	61
Number:	1
Page Range:	S. 81 - 89
Date:	2022
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1651-226X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LONG-TERM SURVIVORS; 2ND CANCER-RISK; RADIATION-THERAPY; INVOLVED-NODE; OPEN-LABEL; MEDIASTINAL RADIATION; MALIGNANT NEOPLASMS; PREMATURE MENOPAUSE; GONADAL-FUNCTION; OVARIAN FAILURE Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58059