Universität zu Köln

Seger, Aline, Gulberti, Alessandro, Vettorazzi, Eik, Braa, Hanna, Buhmann, Carsten, Gerloff, Christian, Hamel, Wolfgang, Moll, Christian K. E. and Poetter-Nerger, Monika (2021). Short Pulse and Conventional Deep Brain Stimulation Equally Improve the Parkinsonian Gait Disorder. J. Parkinsons Dis., 11 (3). S. 1455 - 1465. AMSTERDAM: IOS PRESS. ISSN 1877-718X

Full text not available from this repository.

Abstract

Background: Gait disturbances and balance remain challenging issues in Parkinsonian patients (PD) with deep brain stimulation (DBS). Short pulse deep brain stimulation (spDBS) increases the therapeutic window in PD patients, yet the effect on gait and postural symptoms remains unknown. Objective: We assessed the efficacy of spDBS compared to conventional DBS (cDBS) within the subthalamic nucleus (STN) on Parkinsonian gait. Methods: The study was a single-centre, randomized, double-blind, clinical short-term trial. 20 PD patients were studied postoperatively in three different conditions (DBS stimulation switched off (off DBS), spDBS with 40 mu s pulse width, cDBS with 60 mu s pulse width) on regular medication. The primary endpoint was the relative difference of gait velocity at selfpaced speed during quantitative gait analysis between stimulation conditions. Secondary endpoints were changes of further measures of quantitative gait analysis, Ziegler course, Berg balance scale, FOG questionnaire, MDS-UPDRS, PDQ-39, and HADS. Mixed-model analysis and post-hoc t-tests were performed. Results: Both spDBS and cDBS improved gait velocity at self-paced speed compared to off DBS, however, there was no significant difference between both stimulation modes. Still, 40% of the patients preferred spDBS over cDBS subjectively. Both stimulation modes were equally effective in improving secondary endpoints of gait, balance, motor and non-motor performances. Conclusion: The use of spDBS and cDBS is equally effective in improving gait and balance in PD and might be beneficial in specified cohorts of PD patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Seger, Aline UNSPECIFIED UNSPECIFIED UNSPECIFIED Gulberti, Alessandro UNSPECIFIED UNSPECIFIED UNSPECIFIED Vettorazzi, Eik UNSPECIFIED UNSPECIFIED UNSPECIFIED Braa, Hanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Buhmann, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Gerloff, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamel, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Moll, Christian K. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Poetter-Nerger, Monika UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-580692
DOI:	10.3233/JPD-202492
Journal or Publication Title:	J. Parkinsons Dis.
Volume:	11
Number:	3
Page Range:	S. 1455 - 1465
Date:	2021
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1877-718X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SUBTHALAMIC STIMULATION; DISEASE; WIDTH; NUCLEUS; BALANCE; SCALE Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58069