Universität zu Köln

Persa, Oana D., Koester, Janis ORCID: 0000-0002-5274-0591 and Niessen, Carien M. ORCID: 0000-0002-4892-9391 (2021). Regulation of Cell Polarity and Tissue Architecture in Epidermal Aging and Cancer. J. Invest. Dermatol., 141 (4). S. 1017 - 1024. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1523-1747

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Abstract

The mammalian skin is essential to protect the organism from external damage while at the same time enabling communication with the environment. Aging compromises skin function and regeneration, which is further exacerbated by external influences, such as UVR from the sun. Aging and UVR are also major risk factors contributing to the development of skin cancer. Whereas aging research traditionally has focused on the role of DNA damage and metabolic and stress pathways, less is known about how aging affects tissue architecture and cell dynamics in skin homeostasis and regeneration and whether changes in these processes promote skin cancer. This review highlights how key regulators of cell polarity and adhesion affect epidermal mechanics, tissue architecture, and stem cell dynamics in skin aging and cancer.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Persa, Oana D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koester, Janis UNSPECIFIED orcid.org/0000-0002-5274-0591 UNSPECIFIED Niessen, Carien M. UNSPECIFIED orcid.org/0000-0002-4892-9391 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-581058
DOI:	10.1016/j.jid.2020.12.012
Journal or Publication Title:	J. Invest. Dermatol.
Volume:	141
Number:	4
Page Range:	S. 1017 - 1024
Date:	2021
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1523-1747
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58105