Universität zu Köln

Noster, Janina ORCID: 0000-0002-8802-6605, Thelen, Philipp ORCID: 0000-0001-5073-8829 and Hamprecht, Axel ORCID: 0000-0003-1449-5780 (2021). Detection of Multidrug-Resistant Enterobacterales-From ESBLs to Carbapenemases. Antibiotics-Basel, 10 (9). BASEL: MDPI. ISSN 2079-6382

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Abstract

Multidrug-resistant Enterobacterales (MDRE) are an emerging threat to global health, leading to rising health care costs, morbidity and mortality. Multidrug-resistance is commonly caused by different beta-lactamases (e.g., ESBLs and carbapenemases), sometimes in combination with other resistance mechanisms (e.g., porin loss, efflux). The continuous spread of MDRE among patients in hospital settings and the healthy population require adjustments in healthcare management and routine diagnostics. Rapid and reliable detection of MDRE infections as well as gastrointestinal colonization is key to guide therapy and infection control measures. However, proper implementation of these strategies requires diagnostic methods with short time-to-result, high sensitivity and specificity. Therefore, research on new techniques and improvement of already established protocols is inevitable. In this review, current methods for detection of MDRE are summarized with focus on culture based and molecular techniques, which are useful for the clinical microbiology laboratory.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Noster, Janina UNSPECIFIED orcid.org/0000-0002-8802-6605 UNSPECIFIED Thelen, Philipp UNSPECIFIED orcid.org/0000-0001-5073-8829 UNSPECIFIED Hamprecht, Axel UNSPECIFIED orcid.org/0000-0003-1449-5780 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-582075
DOI:	10.3390/antibiotics10091140
Journal or Publication Title:	Antibiotics-Basel
Volume:	10
Number:	9
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2079-6382
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SPECTRUM-BETA-LACTAMASE; DESORPTION IONIZATION-TIME; RAPIDEC(R) CARBA NP; KLEBSIELLA-PNEUMONIAE; ESCHERICHIA-COLI; MALDI-TOF; ANTIMICROBIAL RESISTANCE; PHENOTYPIC DETECTION; LABORATORY DETECTION; CHROMOGENIC MEDIUM Multiple languages Infectious Diseases; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58207