Universität zu Köln

Diener, Hans Christoph, Gaul, Charly ORCID: 0000-0002-9362-3711, Lehmacher, Walter ORCID: 0000-0003-1672-9309 and Weiser, Thomas (2022). Aspirin, paracetamol (acetaminophen) and caffeine for the treatment of acute migraine attacks: A systemic review and meta-analysis of randomized placebo-controlled trials. Eur. J. Neurol., 29 (1). S. 350 - 358. HOBOKEN: WILEY. ISSN 1468-1331

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Abstract

Background and purpose Many migraine patients rely on over-the-counter analgesics for the treatment of migraine attacks. Fixed-dose combinations of aspirin, paracetamol and caffeine (APC) have been used for treating migraine in many countries for a long time. We performed a meta-analysis for the comparison of APC versus placebo, which has not been done to date. Methods Randomized, blinded, placebo-controlled, parallel-group studies using APC to treat a migraine attack were included in a meta-analysis. We calculated the rate ratio (RRs) associated with APC versus placebo. Results Seven studies were included, with 3306 participants (2147 treated with APC and 1159 treated with placebo). For the primary efficacy outcome, being pain-free at 2 h, APC was superior to placebo (19.6% vs. 9.0%, RR 2.2, 95% confidence interval [CI] 1.4-3.3). For the co-primary efficacy outcome, pain relief at 2 h, APC was superior to placebo (54.3% vs. 31.2%, RR 1.7, 95% CI 1.6-1.9). Adverse events were more frequent in the APC than the placebo groups (10.9% vs. 7.8%, RR 1.7, 95% CI 1.3-2.2). Conclusions Results showed that APC is superior to placebo in the treatment of acute migraine attacks. Efficacy, measured by pain-free response and pain relief at 2 h, was clinically relevant.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Diener, Hans Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaul, Charly UNSPECIFIED orcid.org/0000-0002-9362-3711 UNSPECIFIED Lehmacher, Walter UNSPECIFIED orcid.org/0000-0003-1672-9309 UNSPECIFIED Weiser, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-582294
DOI:	10.1111/ene.15103
Journal or Publication Title:	Eur. J. Neurol.
Volume:	29
Number:	1
Page Range:	S. 350 - 358
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1468-1331
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DOUBLE-BLIND; MULTICENTER; COMBINATION; HEADACHE Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58229