Universität zu Köln

Dederer, Verena and Lemberg, Marius K. (2021). Transmembrane dislocases: a second chance for protein targeting. Trends Cell Biol., 31 (11). S. 898 - 912. LONDON: ELSEVIER SCIENCE LONDON. ISSN 1879-3088

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Abstract

Precise distribution of proteins is essential to sustain the viability of cells. A complex network of protein synthesis and targeting factors cooperate with protein quality control systems to ensure protein homeostasis. Defective proteins are inevitably degraded by the ubiquitin-proteasome system and lysosomes. However, due to overlapping targeting information and limited targeting fidelity, certain proteins become mislocalized. In this review, we present the idea that transmembrane dislocases recognize and remove mislocalized membrane proteins from cellular organelles. This enables other targeting attempts and prevents degradation of mislocalized but otherwise functional proteins. These transmembrane dislocases can be found in the outer mitochondrial membrane (OMM) and endoplasmic reticulum (ER). We highlight common principles regarding client recognition and outline open questions in our understanding of transmembrane dislocases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dederer, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Lemberg, Marius K. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-582556
DOI:	10.1016/j.tcb.2021.05.007
Journal or Publication Title:	Trends Cell Biol.
Volume:	31
Number:	11
Page Range:	S. 898 - 912
Date:	2021
Publisher:	ELSEVIER SCIENCE LONDON
Place of Publication:	LONDON
ISSN:	1879-3088
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TAIL-ANCHORED PROTEINS; QUALITY-CONTROL; AAA-ATPASE; ENDOPLASMIC-RETICULUM; DEGRADATION SIGNALS; PROTEASOME; UBIQUITIN; INSERTION; COMPLEX; MSP1 Multiple languages Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58255