Meyer, Malin Tordis, Watermann, Christoph, Dreyer, Thomas, Wagner, Steffen ORCID: 0000-0003-0873-1601, Wittekindt, Claus, Klussmann, Jens Peter, Erguen, Suleyman, Baumgart-Vogt, Eveline ORCID: 0000-0002-8265-3763 and Karnati, Srikanth ORCID: 0000-0001-9083-2916 (2021). Differential Expression of Peroxisomal Proteins in Distinct Types of Parotid Gland Tumors. Int. J. Mol. Sci., 22 (15). BASEL: MDPI. ISSN 1422-0067

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Abstract

Salivary gland cancers are rare but aggressive tumors that have poor prognosis and lack effective cure. Of those, parotid tumors constitute the majority. Functioning as metabolic machinery contributing to cellular redox balance, peroxisomes have emerged as crucial players in tumorigenesis. Studies on murine and human cells have examined the role of peroxisomes in carcinogenesis with conflicting results. These studies either examined the consequences of altered peroxisomal proliferators or compared their expression in healthy and neoplastic tissues. None, however, examined such differences exclusively in human parotid tissue or extended comparison to peroxisomal proteins and their associated gene expressions. Therefore, we examined differences in peroxisomal dynamics in parotid tumors of different morphologies. Using immunofluorescence and quantitative PCR, we compared the expression levels of key peroxisomal enzymes and proliferators in healthy and neoplastic parotid tissue samples. Three parotid tumor subtypes were examined: pleomorphic adenoma, mucoepidermoid carcinoma and acinic cell carcinoma. We observed higher expression of peroxisomal matrix proteins in neoplastic samples with exceptional down regulation of certain enzymes; however, the degree of expression varied between tumor subtypes. Our findings confirm previous experimental results on other organ tissues and suggest peroxisomes as possible therapeutic targets or markers in all or certain subtypes of parotid neoplasms.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Meyer, Malin TordisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Watermann, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dreyer, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, SteffenUNSPECIFIEDorcid.org/0000-0003-0873-1601UNSPECIFIED
Wittekindt, ClausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klussmann, Jens PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erguen, SuleymanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baumgart-Vogt, EvelineUNSPECIFIEDorcid.org/0000-0002-8265-3763UNSPECIFIED
Karnati, SrikanthUNSPECIFIEDorcid.org/0000-0001-9083-2916UNSPECIFIED
URN: urn:nbn:de:hbz:38-582768
DOI: 10.3390/ijms22157872
Journal or Publication Title: Int. J. Mol. Sci.
Volume: 22
Number: 15
Date: 2021
Publisher: MDPI
Place of Publication: BASEL
ISSN: 1422-0067
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
POSTNATAL-DEVELOPMENT; ABC TRANSPORTERS; LIPID-METABOLISM; CANCER; BIOGENESIS; MOUSE; HALLMARKS; LEADS; INACTIVATION; INVOLVEMENTMultiple languages
Biochemistry & Molecular Biology; Chemistry, MultidisciplinaryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/58276

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