Universität zu Köln

Pfeil, Julia, Hoenig, Merle C., Doering, Elena, van Eimeren, Thilo ORCID: 0000-0002-6951-2325, Drzezga, Alexander ORCID: 0000-0001-6018-716X and Bischof, Gerard N. (2021). Unique regional patterns of amyloid burden predict progression to prodromal and clinical stages of Alzheimer's disease. Neurobiol. Aging, 106. S. 119 - 130. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1558-1497

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Abstract

Although beta-amyloid (A beta) positivity has shown to be associated with higher risk of progression to Alzheimer's disease (AD) in mild cognitive impairment (MCI), information on the time to conversion to manifest dementia cannot be readily deduced from this binary classification. Here, we assessed if regional patterns of A beta deposition measured with F-18-florbetapir may serve as biomarker for progression risk in A beta-positive cognitively normal (CN) and MCI patients, including clinical follow-up data and cerebrospinal fluid (CSF) biomarkers. Voxel-wise group comparisons between age and sex-matched A beta-positive groups (i.e., CN-stables [n = 38] vs. CN-to-MCI/AD progressors [n = 38], MCI-stables [n = 104] versus MCI-toAD progressors [n = 104]) revealed higher A beta burden in precuneus, subcortical, and parietal regions in CN-to-MCI/AD progressors and cingulate, temporal, and frontal regions in MCI-to-AD progressors. Importantly, these regional patterns predicted progression to advanced stages on the AD spectrum in the short and the long-term beyond global A beta burden and CSF biomarkers. These results suggest that distinct regional patterns of A beta burden are a valuable biomarker for risk of disease progression in CN and MCI. (C) 2021 The Authors. Published by Elsevier Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pfeil, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoenig, Merle C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Doering, Elena UNSPECIFIED UNSPECIFIED UNSPECIFIED van Eimeren, Thilo UNSPECIFIED orcid.org/0000-0002-6951-2325 UNSPECIFIED Drzezga, Alexander UNSPECIFIED orcid.org/0000-0001-6018-716X UNSPECIFIED Bischof, Gerard N. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-583595
DOI:	10.1016/j.neurobiolaging.2021.06.014
Journal or Publication Title:	Neurobiol. Aging
Volume:	106
Page Range:	S. 119 - 130
Date:	2021
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1558-1497
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MILD COGNITIVE IMPAIRMENT; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; EPSILON-4 ALLELE; APOLIPOPROTEIN-E; A-BETA; RECOMMENDATIONS; DEPOSITION; DEMENTIA Multiple languages Geriatrics & Gerontology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58359