Universität zu Köln

Bisconti, Marie, Simon, Jean-Francois, Grassi, Sarah, Leroy, Baptiste, Martinet, Baptiste ORCID: 0000-0003-4369-8552, Arcolia, Vanessa, Isachenko, Vladimir ORCID: 0000-0002-3674-543X and Hennebert, Elise ORCID: 0000-0001-7911-4649 (2021). Influence of Risk Factors for Male Infertility on Sperm Protein Composition. Int. J. Mol. Sci., 22 (23). BASEL: MDPI. ISSN 1422-0067

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Abstract

Male infertility is a common health problem that can be influenced by a host of lifestyle risk factors such as environment, nutrition, smoking, stress, and endocrine disruptors. These effects have been largely demonstrated on sperm parameters (e.g., motility, numeration, vitality, DNA integrity). In addition, several studies showed the deregulation of sperm proteins in relation to some of these factors. This review inventories the literature related to the identification of sperm proteins showing abundance variations in response to the four risk factors for male infertility that are the most investigated in this context: obesity, diabetes, tobacco smoking, and exposure to bisphenol-A (BPA). First, we provide an overview of the techniques used to identify deregulated proteins. Then, we summarise the main results obtained in the different studies and provide a compiled list of deregulated proteins in relation to each risk factor. Gene ontology analysis of these deregulated proteins shows that oxidative stress and immune and inflammatory responses are common mechanisms involved in sperm alterations encountered in relation to the risk factors.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bisconti, Marie UNSPECIFIED UNSPECIFIED UNSPECIFIED Simon, Jean-Francois UNSPECIFIED UNSPECIFIED UNSPECIFIED Grassi, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Leroy, Baptiste UNSPECIFIED UNSPECIFIED UNSPECIFIED Martinet, Baptiste UNSPECIFIED orcid.org/0000-0003-4369-8552 UNSPECIFIED Arcolia, Vanessa UNSPECIFIED UNSPECIFIED UNSPECIFIED Isachenko, Vladimir UNSPECIFIED orcid.org/0000-0002-3674-543X UNSPECIFIED Hennebert, Elise UNSPECIFIED orcid.org/0000-0001-7911-4649 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-584239
DOI:	10.3390/ijms222313164
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	22
Number:	23
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACROSIN ACTIVITY; SEMINAL PLASMA; SEMEN QUALITY; OXIDATIVE STRESS; PHOSPHOLIPASE-A2 ACTIVITY; GESTATIONAL EXPOSURE; FUNCTIONAL-ASPECTS; DIABETES-MELLITUS; CIGARETTE-SMOKING; HUMAN SPERMATOZOA Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58423