Universität zu Köln

Schwenk, Philipp, Sheerin, David J., Ponnu, Jathish ORCID: 0000-0002-3276-7068, Staudt, Anne-Marie ORCID: 0000-0002-7667-7769, Lesch, Klara L., Lichtenberg, Elisabeth, Medzihradszky, Katalin F., Hoecker, Ute ORCID: 0000-0002-5636-9777, Klement, Eva, Viczian, Andras and Hiltbrunner, Andreas (2021). Uncovering a novel function of the CCR4-NOT complex in phytochrome A-mediated light signalling in plants. eLife, 10. CAMBRIDGE: eLIFE SCIENCES PUBL LTD. ISSN 2050-084X

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Abstract

Phytochromes are photoreceptors regulating growth and development in plants. Using the model plant Arabidopsis, we identified a novel signalling pathway downstream of the farred light-sensing phytochrome, phyA, that depends on the highly conserved CCR4-NOT complex. CCR4-NOT is integral to RNA metabolism in yeast and animals, but its function in plants is largely unknown. NOT9B, an Arabidopsis homologue of human CNOT9, is a component of the CCR4-NOT complex, and acts as negative regulator of phyA-specific light signalling when bound to NOT1, the scaffold protein of the complex. Light-activated phyA interacts with and displaces NOT9B from NOT1, suggesting a potential mechanism for light signalling through CCR4-NOT. ARGONAUTE 1 and proteins involved in splicing associate with NOT9B and we show that NOT9B is required for specific phyA-dependent alternative splicing events. Furthermore, association with nuclear localised ARGONAUTE 1 raises the possibility that NOT9B and CCR4-NOT are involved in phyA-modulated gene expression.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schwenk, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Sheerin, David J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ponnu, Jathish UNSPECIFIED orcid.org/0000-0002-3276-7068 UNSPECIFIED Staudt, Anne-Marie UNSPECIFIED orcid.org/0000-0002-7667-7769 UNSPECIFIED Lesch, Klara L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lichtenberg, Elisabeth UNSPECIFIED UNSPECIFIED UNSPECIFIED Medzihradszky, Katalin F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoecker, Ute UNSPECIFIED orcid.org/0000-0002-5636-9777 UNSPECIFIED Klement, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Viczian, Andras UNSPECIFIED UNSPECIFIED UNSPECIFIED Hiltbrunner, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-584298
DOI:	10.7554/eLife.63697
Journal or Publication Title:	eLife
Volume:	10
Date:	2021
Publisher:	eLIFE SCIENCES PUBL LTD
Place of Publication:	CAMBRIDGE
ISSN:	2050-084X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MESSENGER-RNA DEADENYLATION; PROMOTE PHOTOMORPHOGENESIS; NUCLEAR ACCUMULATION; SPLICING FACTOR; DISTINCT ROLES; ARABIDOPSIS; MECHANISMS; BODIES; GW182; TRANSCRIPTION Multiple languages Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58429