Universität zu Köln

Loehrer, Philipp Alexander, Nettersheim, Felix Sebastian, Oehrn, Carina Renate ORCID: 0000-0001-8451-7960, Homberg, Fabienne, Tittgemeyer, Marc, Timmermann, Lars and Weber, Immo ORCID: 0000-0003-2979-234X (2021). Increased prefrontal top-down control in older adults predicts motor performance and age-group association. Neuroimage, 240. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-9572

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Abstract

Bimanual motor control declines during ageing, affecting the ability of older adults to maintain independence. An important underlying factor is cortical atrophy, particularly affecting frontal and parietal areas in older adults. As these regions and their interplay are highly involved in bimanual motor preparation, we investigated age-related connectivity changes between prefrontal and premotor areas of young and older adults during the prepara-tory phase of complex bimanual movements using high-density electroencephalography. Generative modelling showed that excitatory inter-hemispheric prefrontal to premotor coupling in older adults predicted age-group affiliation and was associated with poor motor-performance. In contrast, excitatory intra-hemispheric prefrontal to premotor coupling enabled older adults to maintain motor-performance at the cost of lower movement speed. Our results disentangle the complex interplay in the prefrontal-premotor network during movement preparation underlying reduced bimanual control and the well-known speed-accuracy trade-off seen in older adults.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Loehrer, Philipp Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Nettersheim, Felix Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Oehrn, Carina Renate UNSPECIFIED orcid.org/0000-0001-8451-7960 UNSPECIFIED Homberg, Fabienne UNSPECIFIED UNSPECIFIED UNSPECIFIED Tittgemeyer, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Immo UNSPECIFIED orcid.org/0000-0003-2979-234X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-586047
DOI:	10.1016/j.neuroimage.2021.118383
Journal or Publication Title:	Neuroimage
Volume:	240
Date:	2021
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-9572
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTERHEMISPHERIC INTERACTIONS; EFFECTIVE CONNECTIVITY; BIMANUAL MOVEMENTS; PREMOTOR CORTEX; AGING BRAIN; MODULATION; RESPONSES; NETWORK; MODEL; COORDINATION Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58604